SNP Report

Basic Info

Name	rs2439281 dbSNP Ensembl
Location	chr8:32608036 - 32608036(1)
Variant Alleles	T/C
Ancestral Allele	T
Minor Allele	T
Minor Allele Frequence	0.330871
Functional Annotation	intron_variant.
Consequence to Transcript	intron_variant(ENST00000287842, ENST00000356819, ENST00000405005, ENST00000518104, ENST00000518206, ENST00000519301, ENST00000520407, ENST00000521670, ENST00000523079, ENST00000523534, ENST00000631040)
No. of Studies	2 (Positive: 1; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Cao L., 2014	A/G		Total BPI vs. controls: X²=3.57, OR=1.24, 95%CI=1...... Total BPI vs. controls: X²=3.57, OR=1.24, 95%CI=1.00-1.55, Bonf P-value=1; BPI-P vs. controls: X²=0.78, OR=1.12, 95%CI=0.87-1.45, Bonf P-value=1; BPI-NP vs. controls: X²=2, OR=1.29, 95%CI=0.92-1.85, Bonf P-value=1 More...	No significant association was observed. No significant association was observed.	Negative
Wen, Z., 2016	A/G		P-value=0.027,Â OR=1.170, 95%CI=1.018-1.345 P-value=0.027,Â OR=1.170, 95%CI=1.018-1.345	We also identified association between rs2439281, rs11989919...... We also identified association between rs2439281, rs11989919, rs7829383, rs2919375, rs4512342, and bipolar disorder before Bonferroni correction, but no association remained after the correction. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
NRG1	neuregulin 1	8p12	15(10/5/0)

SNPs in LD with rs2439281 (count: 2) View in gBrowse (chr8:32608036..32619298 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Functional Annotation	r²[population]
rs2919370		intron_variant; non_coding_transcript_variant	0.813[CHB]; 1.0[CHD]; 1.0[JPT]
rs2439279		intron_variant	1.0[CHB]; 1.0[CHD]; 1.0[JPT]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)