BDgene

SNP Report

Basic Info
Name rs1386486 dbSNP Ensembl
Location chr12:72018440 - 72018440(1)
Variant Alleles A/G
Ancestral Allele A
Minor Allele G
Minor Allele Frequence 0.463458
Functional Annotation intron_variant.
Consequence to Transcript intron_variant(ENST00000333850)
No. of Studies 4 (Positive: 2; Negative: 2; Trend: 0)
Source Literature
Overlap with SZ? NO
Overlap with MDD? NO

SNP related studies (count: 4)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Cichon, S., 2008 C/T T Cochrane-Armitage trend test P-value > .0.5 in the German BP...... Cochrane-Armitage trend test P-value > .0.5 in the German BPAD sample. Cochrane-Armitage trend test P-value > .0.5 in the Russian BPAD sample. Cochrane-Armitage trend test P-value > .0.5 in Combined German/Russian sample. More... Negative
Roche, S.,2009 T TDT: X2=7.336, P-value = 0.0068 TDT: X2=7.336, P-value = 0.0068 Significant association was observed Significant association was observed Positive
Grigoroiu-Serbanescu, M.,2008 C/T Cochrane-Armitage trend test P value=0.847 Cochrane-Armitage trend test P value=0.847 Negative
Chen, S., 2014 C/T Allele frequency: P-value=0.201646, Permutated P-value=0.560...... Allele frequency: P-value=0.201646, Permutated P-value=0.5609; Genotype frequency: P-value=0.04335, H-W P-value=0.041142(case), H-W P-value=0.303095(control). More... Rs1386486 showed statistically marginal differences between ...... Rs1386486 showed statistically marginal differences between cases and controls in genotype frequencies (P-value=0.043351), but no significant differences in allele distribution. More... Positive

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
TPH2 tryptophan hydroxylase 2 12q15 13(10/3/0)

SNPs in LD with rs1386486 (count: 14) View in gBrowse (chr12:72016002..72022090 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 14)


Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback Acknowledgements
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Last update: March 31, 2016