Gene Report

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Basic Info

Approved Symbol	ZMIZ1
Previous Symbol	RAI17
Symbol Alias	RP11-519K18.1, KIAA1224, FLJ13541, hZIMP10, Zimp10, MIZ
Approved Name	zinc finger, MIZ-type containing 1
Previous Name	retinoic acid induced 17
Location	10q22.3
Position	chr10:79069035-79316528, 1
External Links	HGNC: 16493 Entrez Gene: 57178 Ensembl: ENSG00000108175 UCSC: uc001kaf.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Sklar, P.,2011	SNP: rs780148	No significant association was observed.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0001701	in utero embryonic development	biological process	IEA	17
GO:0008270	zinc ion binding	molecular function	IEA	77
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0048844	artery morphogenesis	biological process	IEA	6
GO:0048146	positive regulation of fibroblast proliferation	biological process	IEA	7
GO:0016607	nuclear speck	cellular component	IEA	16
GO:0043231	intracellular membrane-bounded organelle	cellular component	IDA	34
GO:0007296	vitellogenesis	biological process	IEA	1
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IEA	91
GO:0048589	developmental growth	biological process	IEA	7
GO:0001570	vasculogenesis	biological process	IEA	4
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0007569	cell aging	biological process	IEA	5
GO:0003007	heart morphogenesis	biological process	IEA	5
GO:0005737	cytoplasm	cellular component	IEA	322

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ZMIZ1	TBC1D4	NO	yeast 2-hybrid	12421765
ZMIZ1	AR	NO	in vitro;in vivo	14609956
ZMIZ1	CACHD1	NO	yeast 2-hybrid	12421765
ZMIZ1	CNTNAP2	NO	yeast 2-hybrid	12421765

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs780148	chr10:79175326 - 79175326(1)	intron_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
10q22.3-23.32	chr10:75900000-92300000	1 (0/1/0)
10q22.1-q24.1	chr10:68800000-97500000	1 (1/0/0)
10q22.3-24.1	chr10:75900000-97500000	1 (0/1/0)
Chr 10	chr10:0-133797422	3 (0/2/1)
10q22	chr10:68800000-80300000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr10:79069035..79316528 View in gBrowse