BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Turecki, G.,2000 PMID: 10760559
Citation	Turecki, G., M. Alda, et al. (2000). "Polyglutamine coding genes in bipolar disorder: lack of association with selected candidate loci." J Affect Disord 58(1): 63-68.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	138 cases and 108 controls
SNP/Region/Marker Size	5 variants
Predominant Ethnicity	Caucasian
Population	Austrian, Canadian,Czech, Danish, German, and Swedish
Gender	The sex ratio(M/F) was 0.87 for BD patients and 0.86 for controls
Age Group	Adults : Mean age(SD)(year):50.0(14.4),27.6(9.9) at onset for BD patients and 51.5(14.8) for controls

Detail Info

Sample Diagnosis	RDC
Sample Status	Subjects included in this study were 138 patients and 108 screened normal controls that were collected in centers that collaborate in the International Group for the Study of Lithium (IGSLi). Research clinics in Austria, Germany, Denmark, Sweden, Czech Republic and Canada contributed 3, 23, 7, 17, 20 and 68 patients, respectively. Controls were married-insubjects from a family study of this patient population or healthy volunteers of the same ethnic background as cases. All patients and controls were Caucasians of European (non-Mediterranean) descent.
Technique	PCR and sequencing
Statistical Method	Alleles and genotype distributions were compared between groups using the method respecproposed by Curtis and Sham that estimates empirical P values using a Monte Carlo approach (Sham and Curtis, 1995).
Result Summary	No difference was found in allele distribution between cases and controls for any of the loci studied. In one locus - L10378 - patients had a tendency to present shorter alleles (28.1 versus 27.9 repeats; t=2.55, df=205, P=0.011), however, this difference disappeared after correction for multiple testing. LIMITATIONS: The study has limitations common to most candidate gene association studies, that is, limited number of loci investigated and limited power to detect loci that account for a small proportion of the total genetic variability. Our results suggest that the loci investigated have no major role in the genetic predisposition to bipolar disorder.

Other variants reported by this study for BD (count: 1)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
TBP CAG/CAA repeats	TBP	microsatellite	CAG/CAA repeats		Association analysis:Monte Carlo approach, P-value > 0.05	No significant association was observed in BD. No significant association was observed in BD.	Negative

Genes reported by this study for BD (count: 1)

Regions reported by this study for BD (count: 4)

Region	Statistical Values	Author Comments	Result Category
16q13	Association analysis: Monte Carlo approach, t = 2.55, df = 205, P-value = 0.011(P-value > 0.05 after correction)	No significant association was observed in BD. No significant association was observed in BD.	Negative
2q32.3-q33	Association analysis: Monte Carlo approach, P-value > 0.05	No significant association was observed in BD. No significant association was observed in BD.	Negative
22q11.2	Association analysis: Monte Carlo approach, P-value > 0.05	No significant association was observed in BD. No significant association was observed in BD.	Negative
Chr 17	Association analysis: Monte Carlo approach, P-value > 0.05	No significant association was observed in BD. No significant association was observed in BD.	Negative