Gene Report

Basic Info
Approved Symbol SPR
Symbol Alias SDR38C1
Approved Name sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
Name Alias short chain dehydrogenase/reductase family 38C, member 1
Location 2p14-p12
Position chr2:72887360-72892158, 1
External Links HGNC: 11257
Entrez Gene: 6697
Ensembl: ENSG00000116096
UCSC: uc002sik.2
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
McHugh, P. C.,2009 Haplotype: rs2421095 - rs1876487(A-A, A-A), rs2421095 - rs1876487(A-A, A-G), rs2421095 - rs1876487(C-A, A-A), rs2421095 - rs1876487(C-A, A-G), rs2421095 - rs1876487(C-A, C-A) In conclusion, evidence is presented for an association between a particular SPR promoter haplotype pair 2, 3 and occurrence of bipolar I disorder. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 23)

GO terms by PBA (count: 0)

GO terms by database search (count: 23)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr2:72887360..72892158 View in gBrowse
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