Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	PSMB9
Previous Symbol	LMP2
Symbol Alias	RING12, beta1i, PSMB6i
Approved Name	proteasome (prosome, macropain) subunit, beta type, 9
Previous Name	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional protease 2), "large multifunctional peptidase 2"
Location	6p21.3
Position	chr6:32844136-32859585, 1
External Links	HGNC: 9546 Entrez Gene: 5698 Ensembl: ENSG00000240065 UCSC: uc003sga.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value < 0.0001. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 30)

GO terms by PBA (count: 0)

GO terms by database search (count: 30)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0042981	regulation of apoptotic process	biological process	TAS	10
GO:0000502	proteasome complex	cellular component	TAS[8666937]	2
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition	biological process	TAS	2
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0070062	extracellular vesicular exosome	cellular component	IDA[20458337]	176
GO:0004298	threonine-type endopeptidase activity	molecular function	IEA	1
GO:0006521	regulation of cellular amino acid metabolic process	biological process	TAS	3
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	biological process	TAS	2
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	biological process	TAS	5
GO:0005829	cytosol	cellular component	TAS	223
GO:0016032	viral process	biological process	TAS	26
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	biological process	TAS	1
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	biological process	TAS	3
GO:0005515	protein binding	molecular function	IPI[14733938]	563
GO:0005654	nucleoplasm	cellular component	TAS	163
GO:0000082	G1/S transition of mitotic cell cycle	biological process	TAS	9
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	biological process	TAS	7
GO:0090263	positive regulation of canonical Wnt signaling pathway	biological process	TAS	9
GO:0010467	gene expression	biological process	TAS	41
GO:1990111	spermatoproteasome complex	cellular component	ISS	1
GO:0000278	mitotic cell cycle	biological process	TAS	33
GO:0005839	proteasome core complex	cellular component	ISS	1
GO:0043066	negative regulation of apoptotic process	biological process	TAS	46
GO:0006915	apoptotic process	biological process	TAS	39
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS	20
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	biological process	TAS	5
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	biological process	TAS	2
GO:0090090	negative regulation of canonical Wnt signaling pathway	biological process	TAS	9
GO:0000209	protein polyubiquitination	biological process	TAS	7

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PSMB9	NCOA3	NO	in vitro;yeast 2-hybrid	16957778
PSMB9	PSMB10	NO	in vivo	10329130
PSMB9	NCOA2	NO	in vitro;yeast 2-hybrid	16957778
PSMB9	NCOA1	NO	in vitro;in vivo;yeast 2-hybrid	16957778

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6p21	chr6:30500000-46200000	1 (0/1/0)
6p23-p21.1	chr6:13400000-46200000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr6:32844136..32859585 View in gBrowse