Gene Report

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Basic Info

Approved Symbol	GSPT1
Symbol Alias	GST1, ETF3A, eRF3a
Approved Name	G1 to S phase transition 1
Location	16p13.1
Position	chr16:11868128-11916082, -1
External Links	HGNC: 4621 Entrez Gene: 2935 Ensembl: ENSG00000103342 UCSC: uc002dbt.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Georgi, B., 2014	SNP: rs11544193	Putative damaging exonic variant was found within this gene.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005515	protein binding	molecular function	IPI[12489690]	563
GO:0044822	poly(A) RNA binding	molecular function	IDA[22658674]	44
GO:0003747	translation release factor activity	molecular function	IMP[15326224]	1
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	biological process	TAS[15326224]	3
GO:0006479	protein methylation	biological process	IDA[18539146]	2
GO:0005622	intracellular	cellular component	NAS[15326224]	17
GO:0000082	G1/S transition of mitotic cell cycle	biological process	TAS[2511002]	9
GO:0003924	GTPase activity	molecular function	TAS[15326224]	14
GO:0006415	translational termination	biological process	IMP[15326224]	1
GO:0005525	GTP binding	molecular function	IEA	20

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 8)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
GSPT1	PABPC1	NO	in vitro;in vivo	10358005 , 18056425
GSPT1	ATXN1	YES	yeast 2-hybrid	16713569
GSPT1	XIAP	NO	in vitro;in vivo	12865429
GSPT1	BIRC2	NO	in vitro	12865429
GSPT1	ETF1	YES	in vivo;yeast 2-hybrid	9928949 , 9712840
GSPT1	BIRC3	NO	in vitro	12865429
GSPT1	GSPT2	NO	in vivo;yeast 2-hybrid	9712840
GSPT1	CDKN2A	YES	in vitro;in vivo;yeast 2-hybrid	16582619

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs11544193	chr16:11915447 - 11915447(1)	intron_variant; missense_variant; upstream_gene_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 16	chr16:0-90338345	5 (1/3/1)
16p12.3-p13.1	chr16:10400000-21200000	1 (1/0/0)
16p13	chr16:10400000-16700000	4 (1/0/3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr16:11868128..11916082 View in gBrowse