Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	CUL1
Approved Name	cullin 1
Location	7q36.1
Position	chr7:148697914-148801036, 1
External Links	HGNC: 2551 Entrez Gene: 8454 Ensembl: ENSG00000055130 UCSC: uc003wey.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Chen, X., 2015	SNP: rs1029888	CUL1 has been implicated in Alzheimerâ€™s disease.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 24)

GO terms by PBA (count: 0)

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0000278	mitotic cell cycle	biological process	TAS	33
GO:0000082	G1/S transition of mitotic cell cycle	biological process	TAS	9
GO:0016567	protein ubiquitination	biological process	IDA[15103331]	18
GO:0008285	negative regulation of cell proliferation	biological process	TAS[8681378]	41
GO:0005654	nucleoplasm	cellular component	TAS	163
GO:1990452	Parkin-FBXW7-Cul1 ubiquitin ligase complex	cellular component	IPI[12628165]	2
GO:0007050	cell cycle arrest	biological process	TAS[8681378]	10
GO:0006513	protein monoubiquitination	biological process	IEA	2
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	biological process	TAS	3
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	biological process	TAS	2
GO:0007219	Notch signaling pathway	biological process	TAS	14
GO:0016032	viral process	biological process	IEA	26
GO:0008283	cell proliferation	biological process	IEA	37
GO:0000086	G2/M transition of mitotic cell cycle	biological process	TAS	15
GO:0005829	cytosol	cellular component	TAS	223
GO:0031461	cullin-RING ubiquitin ligase complex	cellular component	IDA[22405651]	1
GO:0019005	SCF ubiquitin ligase complex	cellular component	IDA[15103331]; ISS	2
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	biological process	IDA[15103331]; ISS	1
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition	biological process	TAS	2
GO:0005515	protein binding	molecular function	IPI[11961546]	563
GO:0097193	intrinsic apoptotic signaling pathway	biological process	TAS[8681378]	8
GO:0009887	organ morphogenesis	biological process	IEA	9
GO:0031625	ubiquitin protein ligase binding	molecular function	IEA	25
GO:0007623	circadian rhythm	biological process	TAS	40

Gene related KEGG pathways (count: 4)

KEGG pathways by PBA (count: 3)

ID	Name	No. of Genes in BDgene
hsa04110	Cell cycle	8
hsa04120	Ubiquitin mediated proteolysis	4
hsa04350	TGF-beta signaling pathway	10

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04310	Wnt signaling pathway	20

Gene related BioCarta pathways (count: 4)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 4)

ID	Name	No. of Genes in BDgene
p27Pathway	Regulation of p27 Phosphorylation during Cell Cycle Progression	1
eradPathway	ER-associated degradation (ERAD) Pathway	1
skp2e2fPathway	E2F1 Destruction Pathway	1
fbw7Pathway	Cyclin E Destruction Pathway	1

Gene related interactors from protein-protein interactions data in HPRD (count: 32)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
CUL1	PPP1CA	NO	in vitro;in vivo	17274640
CUL1	FBXO18	YES	in vivo	11956208
CUL1	SKP1	NO	in vitro;in vivo	9827542 , 17290223
CUL1	CHUK	NO	in vivo	17914462
CUL1	E2F1	NO	in vitro;in vivo	10559858
CUL1	FBXW7	NO	in vitro	14603323
CUL1	RBX1	YES	in vitro	11961546
CUL1	FBXW4	NO	in vitro	14603323
CUL1	CDCA3	NO	in vitro;in vivo	12679038
CUL1	RAC2	NO	yeast 2-hybrid	11445862
CUL1	NFKBIA	NO	in vitro	14743216
CUL1	PRPF40A	NO	in vitro	14603323
CUL1	GPS1	NO	in vivo	11337588
CUL1	FBXW11	NO	in vitro;in vivo	14603323
CUL1	CDC34	NO	in vitro	16123592
CUL1	NEDD8	NO	in vitro;in vivo	10772955 , 10713156 , 16620772 , 17914462
CUL1	FBXO25	NO	in vivo	16278047
CUL1	FBXW2	NO	in vitro	14603323
CUL1	COPS6	NO	in vitro	11337588
CUL1	SMAD3	NO	in vivo	11359933
CUL1	NFKBIB	NO	in vitro	14743216
CUL1	RNF7	NO	in vivo;yeast 2-hybrid	10230407
CUL1	BTRC	NO	in vitro;in vivo	14603323
CUL1	NR1D2	NO	yeast 2-hybrid	15604093
CUL1	COMMD1	NO	in vivo	14685242
CUL1	NLK	NO	in vivo	18765672
CUL1	CHEK1	YES	in vivo	16137618 , 17290223
CUL1	NFKBIE	NO	in vitro	14743216
CUL1	SKP2	NO	in vitro;in vivo	9430629
CUL1	CDK9	NO	in vivo	12861003 , 11689688
CUL1	HIPK2	NO	in vivo	18765672
CUL1	CAND1	NO	in vitro	12609982 , 12504026

Related other genetic factors

Gene related SNPs (count: 26)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1029888	chr7:148772624 - 148772624(1)	intron_variant	1(1/0/0)

LD-proxies (count: 25)

rs_ID	Location	Functional Annotation
rs243495	chr7:148744308 - 148744308(1)	intron_variant
rs243487	chr7:148751119 - 148751119(1)	intron_variant
rs243486	chr7:148751129 - 148751129(1)	intron_variant
rs243480	chr7:148755813 - 148755813(1)	intron_variant
rs10255478	chr7:148804893 - 148804893(1)	downstream_gene_variant
rs9987055	chr7:148804666 - 148804666(1)	downstream_gene_variant
rs7802887	chr7:148797666 - 148797666(1)	intron_variant
rs1019218	chr7:148791872 - 148791872(1)	intron_variant
rs10225300	chr7:148804915 - 148804915(1)	downstream_gene_variant
rs6464925	chr7:148770936 - 148770936(1)	intron_variant
rs740951	chr7:148773068 - 148773068(1)	intron_variant
rs1014095	chr7:148766768 - 148766768(1)	intron_variant
rs6956231	chr7:148767583 - 148767583(1)	intron_variant
rs10216219	chr7:148781628 - 148781628(1)	intron_variant
rs10215794	chr7:148781803 - 148781803(1)	intron_variant
rs3823637	chr7:148777174 - 148777174(1)	intron_variant
rs6977453	chr7:148777654 - 148777654(1)	intron_variant
rs1558420	chr7:148783022 - 148783022(1)	intron_variant
rs1558419	chr7:148783141 - 148783141(1)	intron_variant
rs10215159	chr7:148781979 - 148781979(1)	intron_variant
rs3800949	chr7:148782556 - 148782556(1)	intron_variant
rs933436	chr7:148790237 - 148790237(1)	intron_variant
rs2007404	chr7:148790303 - 148790303(1)	intron_variant; splice_region_variant
rs10241408	chr7:148784396 - 148784396(1)	intron_variant
rs2072406	chr7:148786668 - 148786668(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 7	chr7:0-159345973	3 (0/3/0)
7q34-qter	chr7:138500000-159345973	1 (0/1/0)
7q36	chr7:148200000-159345973	3 (0/0/3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr7:148697914..148801036 View in gBrowse