BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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KEGG Pathway Report

Basic Info

ID	hsa04120
Name	Ubiquitin mediated proteolysis
No. of Genes in BDgene	4
Source	Pathway by PBA

PBA Result

Pathway Name in Paper	Source	Reference	Data Set	Tool	Result Parameters	Result Link
Ubiquitin mediated proteolysis	PBA paper	Chang, S., 2015	group B	i-GSEA4GWAS v2, GenGen, SRT	FDR=0.019 (B) by i-GSEA4GWAS v2; FDR=0.002 (B) by GenGen; FDR=0.021 (B) by SRT

Pathway related genes in BDgene (count: 4)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
CUL1	cullin 1	7q36.1	1(1/0/0)
UBE2L3	ubiquitin-conjugating enzyme E2L 3	22q11.2	1(0/1/0)
UBE2E2	ubiquitin-conjugating enzyme E2E 2	3p24.2	1(0/1/0)
PARK2	parkin RBR E3 ubiquitin protein ligase	6q25.2-q27	1(1/0/0)