Gene Report

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Basic Info

Approved Symbol	AHSA2
Symbol Alias	DKFZp564C236, Hch1
Approved Name	AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)
Location	2p14
Position	chr2:61177418-61191203, 1
External Links	HGNC: 20437 Entrez Gene: 130872 Ensembl: ENSG00000173209 UCSC: uc002sbc.2
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Georgi, B., 2014	SNP: rs200746889	Amish-specific putative damaging exonic missense variant was found within this gene.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0032781	positive regulation of ATPase activity	biological process	IEA	2
GO:0001671	ATPase activator activity	molecular function	IEA	2
GO:0051087	chaperone binding	molecular function	IEA	10
GO:0005515	protein binding	molecular function	IPI[25416956]	563

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
AHSA2	HSP90AA1	YES	in vivo;yeast 2-hybrid	12504007 , 14739935 , 12604615

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs200746889	chr2:61186626 - 61186626(1)	3_prime_UTR_variant; downstream_gene_variant; missense_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2p16.1-q11.2	chr2:54700000-102100000	1 (1/0/0)
2p16.2-p11.2	chr2:52600000-91800000	1 (1/0/0)
2p13-16	chr2:47500000-71300000	1 (0/0/1)
Chr 2	chr2:0-242193529	3 (0/3/0)
2p22.2-p13.3	chr2:36300000-71300000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr2:61177418..61191203 View in gBrowse