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Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Enriched Pathway for Shared Genes from Cross-disorder Studies

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The pathway enrichment analyses for positive shared genes from cross-disorder studies were done by DAVID.

The genes for pathway enrichment analysis include:

Enrichment analysis result:

Enriched pathway for BD-SZ shared genes (count: 10)
Enriched pathway for BD-MDD shared genes (count: 10)

Filter Enriched Pathway

Enriched pathway for BD-SZ shared genes (count: 10)

	Category	ID	Name	Mapped Gene Count	Total Gene Count	P-value	Benjamini	FDR	Genes
1	GOTERM_BP_FAT	GO:0007268	synaptic transmission	15	298	1.91E-9	1.31E-6	3.14E-6	15 genes NOS1 DRD2 SLC6A4 GRIK4 CACNB2 COMT ATXN1 GRM4 GRM3 GRIN2B CHRNB4 CHRNA5 CACNA1C CHRNA3 HTR2A
2	GOTERM_BP_FAT	GO:0007610	behavior	18	469	1.53E-9	2.1E-6	2.52E-6	18 genes MCHR1 GNB1L DRD2 COMT ATXN1 GRM4 BDNF NPAS2 NPAS3 GRIN2B CHRNB4 SLC18A2 CHRNA5 IL1B RELN CACNA1C CHRNA3 HTR2A
3	GOTERM_BP_FAT	GO:0007611	learning or memory	9	111	2.83E-7	4.85E-5	4.65E-4	9 genes ATXN1 GRM4 BDNF GRIN2B DRD2 IL1B COMT CACNA1C HTR2A
4	GOTERM_BP_FAT	GO:0019226	transmission of nerve impulse	15	350	1.49E-8	6.83E-6	2.46E-5	15 genes NOS1 DRD2 SLC6A4 GRIK4 CACNB2 COMT ATXN1 GRM4 GRM3 GRIN2B CHRNB4 CHRNA5 CACNA1C CHRNA3 HTR2A
5	GOTERM_CC_FAT	GO:0030425	dendrite	11	163	6.59E-8	1.16E-5	8.09E-5	11 genes GRM3 NOS1 GRIN2B DRD2 GRIK4 CHRNA5 RELN DPYSL2 CACNA1C CHRNA3 HTR2A
6	GOTERM_BP_FAT	GO:0031644	regulation of neurological system process	10	153	2.8E-7	5.48E-5	4.6E-4	10 genes BDNF GRM3 YWHAH TNF GRIN2B DRD2 CHRNB4 SYNGR1 CHRNA3 HTR2A
7	GOTERM_BP_FAT	GO:0044057	regulation of system process	13	309	2.45E-7	5.6E-5	4.02E-4	13 genes NOS1 TNF DRD2 SYNGR1 BDNF GRM3 YWHAH GRIN2B CHRNB4 IL1B CACNA1C CHRNA3 HTR2A
8	GOTERM_BP_FAT	GO:0050804	regulation of synaptic transmission	10	136	1.02E-7	3.49E-5	1.67E-4	10 genes BDNF GRM3 YWHAH TNF GRIN2B DRD2 CHRNB4 SYNGR1 CHRNA3 HTR2A
9	GOTERM_BP_FAT	GO:0051969	regulation of transmission of nerve impulse	10	147	1.99E-7	5.45E-5	3.27E-4	10 genes BDNF GRM3 YWHAH TNF GRIN2B DRD2 CHRNB4 SYNGR1 CHRNA3 HTR2A
10	KEGG_PATHWAY	hsa04710:Circadian rhythm		6	13	1.23E-7	1.2E-5	1.36E-4	6 genes NPAS2 CRY2 CSNK1E PER2 PER1 PER3

Enriched pathway for BD-MDD shared genes (count: 10)

	Category	ID	Name	Mapped Gene Count	Total Gene Count	P-value	Benjamini	FDR	Genes
1	GOTERM_BP_FAT	GO:0007267	cell-cell signaling	16	600	1.65E-9	5.33E-7	2.6E-6	16 genes DRD2 MAOA SLC6A4 DRD4 TH GABRA5 CACNB2 COMT VIPR2 ADCYAP1 GRM3 BDNF P2RX7 GPR50 CACNA1C HTR2C
2	GOTERM_BP_FAT	GO:0007268	synaptic transmission	12	298	6.82E-9	1.65E-6	1.07E-5	12 genes P2RX7 GRM3 DRD2 MAOA TH DRD4 SLC6A4 GABRA5 CACNB2 COMT CACNA1C HTR2C
3	GOTERM_BP_FAT	GO:0007610	behavior	12	469	6.84E-7	9.48E-5	0.00108	12 genes NPAS2 BDNF HTR1A DRD2 WFS1 MAOA TH DRD4 GABRA5 COMT CACNA1C HTR2C
4	GOTERM_BP_FAT	GO:0007623	circadian rhythm	9	46	3.83E-12	3.71E-9	6.02E-9	9 genes NPAS2 NR1D1 DRD2 PER2 PROKR2 ARNTL PER3 CRY1 CLOCK
5	GOTERM_BP_FAT	GO:0019226	transmission of nerve impulse	12	350	3.59E-8	6.97E-6	5.65E-5	12 genes P2RX7 GRM3 DRD2 MAOA TH DRD4 SLC6A4 GABRA5 CACNB2 COMT CACNA1C HTR2C
6	GOTERM_BP_FAT	GO:0044057	regulation of system process	11	309	1.25E-7	2.02E-5	1.96E-4	11 genes ACE BDNF GRM3 DRD2 GRIK3 TH DRD4 AVPR1B NOS3 CACNA1C HTR2C
7	GOTERM_CC_FAT	GO:0044459	plasma membrane part	25	2203	2.11E-8	2.8E-6	2.46E-5	25 genes DRD2 GRIK3 SLC6A4 DRD4 TH CACNB2 COMT VIPR2 ACE HTR1A CSF2RB NOS3 MAOA GABRA5 HTR4 CTLA4 CRHR1 CRHR2 SYNE1 P2RX7 GRM3 AVPR1B GPR50 CACNA1C HTR2C
8	GOTERM_BP_FAT	GO:0048511	rhythmic process	11	128	2.42E-11	1.18E-8	3.81E-8	11 genes NPAS2 NR1D1 DRD2 PER2 PROKR2 NOS3 ARNTL ARNTL2 PER3 CRY1 CLOCK
9	KEGG_PATHWAY	hsa04080:Neuroactive ligand-receptor interaction		15	256	6.64E-10	1.43E-8	6.18E-7	15 genes DRD2 GRIK3 DRD4 GABRA5 HTR4 VIPR2 CRHR1 CRHR2 P2RX7 TAAR6 GRM3 HTR1A AVPR1B GPR50 HTR2C
10	KEGG_PATHWAY	hsa04710:Circadian rhythm		7	13	1.35E-10	5.79E-9	1.25E-7	7 genes NPAS2 NR1D1 PER2 ARNTL PER3 CRY1 CLOCK