BDgene

Enriched Pathway for Shared Genes from Cross-disorder Studies

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The genes for pathway enrichment analysis include:

Enrichment analysis result:

Filter Enriched Pathway

Top e.g. 10, P-value < e.g. 1.0E-3 Total Gene Count < e.g. 350,

Enriched pathway for BD-SZ shared genes (count: 10)
Category ID Name Mapped Gene Count Total Gene Count P-value Benjamini FDR Genes
1 GOTERM_BP_FAT GO:0007610 behavior 18 469 1.53E-9 2.1E-6 2.52E-6 18 genes
2 GOTERM_BP_FAT GO:0007268 synaptic transmission 15 298 1.91E-9 1.31E-6 3.14E-6 15 genes
3 GOTERM_BP_FAT GO:0019226 transmission of nerve impulse 15 350 1.49E-8 6.83E-6 2.46E-5 15 genes
4 GOTERM_CC_FAT GO:0030425 dendrite 11 163 6.59E-8 1.16E-5 8.09E-5 11 genes
5 KEGG_PATHWAY hsa04710:Circadian rhythm 6 13 1.23E-7 1.2E-5 1.36E-4 6 genes
6 GOTERM_BP_FAT GO:0050804 regulation of synaptic transmission 10 136 1.02E-7 3.49E-5 1.67E-4 10 genes
7 GOTERM_BP_FAT GO:0051969 regulation of transmission of nerve impulse 10 147 1.99E-7 5.45E-5 3.27E-4 10 genes
8 GOTERM_BP_FAT GO:0044057 regulation of system process 13 309 2.45E-7 5.6E-5 4.02E-4 13 genes
9 GOTERM_BP_FAT GO:0031644 regulation of neurological system process 10 153 2.8E-7 5.48E-5 4.6E-4 10 genes
10 GOTERM_BP_FAT GO:0007611 learning or memory 9 111 2.83E-7 4.85E-5 4.65E-4 9 genes

Enriched pathway for BD-MDD shared genes (count: 10)
Category ID Name Mapped Gene Count Total Gene Count P-value Benjamini FDR Genes
1 GOTERM_BP_FAT GO:0007623 circadian rhythm 9 46 3.83E-12 3.71E-9 6.02E-9 9 genes
2 GOTERM_BP_FAT GO:0048511 rhythmic process 11 128 2.42E-11 1.18E-8 3.81E-8 11 genes
3 KEGG_PATHWAY hsa04710:Circadian rhythm 7 13 1.35E-10 5.79E-9 1.25E-7 7 genes
4 KEGG_PATHWAY hsa04080:Neuroactive ligand-receptor interaction 15 256 6.64E-10 1.43E-8 6.18E-7 15 genes
5 GOTERM_BP_FAT GO:0007267 cell-cell signaling 16 600 1.65E-9 5.33E-7 2.6E-6 16 genes
6 GOTERM_BP_FAT GO:0007268 synaptic transmission 12 298 6.82E-9 1.65E-6 1.07E-5 12 genes
7 GOTERM_CC_FAT GO:0044459 plasma membrane part 25 2203 2.11E-8 2.8E-6 2.46E-5 25 genes
8 GOTERM_BP_FAT GO:0019226 transmission of nerve impulse 12 350 3.59E-8 6.97E-6 5.65E-5 12 genes
9 GOTERM_BP_FAT GO:0044057 regulation of system process 11 309 1.25E-7 2.02E-5 1.96E-4 11 genes
10 GOTERM_BP_FAT GO:0007610 behavior 12 469 6.84E-7 9.48E-5 0.00108 12 genes