BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Other Variant Report

Basic Info

Name	TH TaqI Polymorphism
Type	SNP
Related Gene	TH
No. of Study	4 (Positive: 2; Negative 2; Trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	YES

Variant related studies (count: 4)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Leboyer, M.,1990			The relative risks of 2.99(TaqI) are significant (p-value<0.01)	Our results demonstrated an association between RFLP and bip..... More Our results demonstrated an association between RFLP and bipolar illness. Less	Positive
Gill, M., 1991			X² = 1.7, P-value>0.05	No evidence support the association of this variant with BD	Negative
Souery, D.,1996(a)			Fisher's exact test:genotype, Fi = 6.92; p = 0.032;homozygotes-heterozygotes distribution,Fi = 6.28; p = 0.01	Statistically significant associations were found.	Positive
De bruyn, A.,1994			chi square tests:all P-value >0.05	No evidence support the association of this variant with BD	Negative

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Souery, D.,1996(a)	Fisher's exact test:genotype, Fi = 9.99; p = 0.002;homozygotes-heterozygotes distribution,Fi = 6.28; p = 0.01	There was a significant difference between patients with unipolar disorder and controls.	Positive