BDgene

Other Variant Report

Basic Info
Name TH TaqI Polymorphism
Type SNP
Related Gene TH
No. of Study 4 (Positive: 2; Negative 2; Trend: 0)
Overlap with SZ? NO
Overlap with MDD? YES

Variant related studies (count: 4)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Leboyer, M.,1990 The relative risks of 2.99(TaqI) are significant (p-value<0.01)
Our results demonstrated an association between RFLP and bip..... More
Positive
Gill, M., 1991 X2 = 1.7, P-value>0.05 No evidence support the association of this variant with BD Negative
Souery, D.,1996(a) Fisher's exact test:genotype, Fi = 6.92; p = 0.032;homozygotes-heterozygotes distribution,Fi = 6.28; p = 0.01 Statistically significant associations were found. Positive
De bruyn, A.,1994 chi square tests:all P-value >0.05 No evidence support the association of this variant with BD Negative

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Souery, D.,1996(a) Fisher's exact test:genotype, Fi = 9.99; p = 0.002;homozygotes-heterozygotes distribution,Fi = 6.28; p = 0.01 There was a significant difference between patients with unipolar disorder and controls. Positive