BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Basic Info

Name	TH PstI Polymorphism
Type	SNP
Related Gene	TH
No. of Study	3 (Positive: 0; Negative 3; Trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	YES

Variant related studies (count: 3)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Furlong, R. A.,1999(c)			For Cambridge bipolar vs. control: alleles, chi squre = 0.417, 1 df, P-value = 0.52; genotypes, chi squre = 0.530, 2df, P-value = 0.77;	No significant differences were found in bipolar groups.	Negative
Inayama, Y., 1993			chi square tests:all P-value >0.05	No evidence support the association of this variant with BD	Negative
De bruyn, A.,1994			chi square tests:all P-value >0.05	No evidence support the association of this variant with BD	Negative

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Furlong, R. A.,1999(c)	For Cambridge unipolar vs. control: alleles, chi squre = 3.946, 1 df, P-value = 0.047; genotypes, chi squre = 4.436, 2 df, P-value = 0.11; for Edinburgh unipolar vs. control: alleles, chi squre = 0.661, 1df, P-value = 0.42; genotypes, chi squre = 2.274, 2 df, P-value = 0.32.	Significant differences were found in Cambridge unipolar groups.	Positive