BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Other Variant Report

Basic Info

Name	DRD3 BalI Polymorphism
Type	point mutation
Related Gene	DRD3
No. of Study	6 (Positive: 1; Negative 5; Trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Variant related studies (count: 6)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Rietschel, M.,1993	A/G		allelic P-value = 0.69, X² = 0.16	The variant in DRD3 altering the amino acid sequence of the ..... More The variant in DRD3 altering the amino acid sequence of the protein can be regarded as a variant with no major effect on the susceptibility to bipolar affective disorder Less	Negative
Souery, D.,1996(b)			Fisher's exact test:all P-value >0.05	No significant differences were found in bipolar groups.	Negative
Kirov, G.,1999(a)			TDT:chi square = 0.27, 1 df, P = 0.6	No significant differences were found in bipolar groups.	Negative
Mitchell, P.,1993			chi square tests:all P-value >0.05	No evidence support the association of this variant with BD	Negative
Parsian, A.,1995			case-control:p-value = 0.13; When using the transmitted allele relative risk approach, p-value = 0.04	Result suggested a association of this variant with BD	Positive
Elvidge, G.,2001			Association analysis:chi square tests, chi-square=0.01, allele P-value = 0.92, 1 df.Meta analysis:odds ratio, OR, = 1.04; P-value = 0.60; 95% confidence interval, CI, = 0.89-1.20	No significant association was observed in BD.	Negative

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)