BDgene

Other Variant Report

Basic Info
Name DRD3 BalI Polymorphism
Type point mutation
Related Gene DRD3
No. of Study 6 (Positive: 1; Negative 5; Trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO

Variant related studies (count: 6)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Rietschel, M.,1993 A/G allelic P-value = 0.69, X2 = 0.16
The variant in DRD3 altering the amino acid sequence of the ..... More
Negative
Souery, D.,1996(b) Fisher's exact test:all P-value >0.05 No significant differences were found in bipolar groups. Negative
Kirov, G.,1999(a) TDT:chi square = 0.27, 1 df, P = 0.6 No significant differences were found in bipolar groups. Negative
Mitchell, P.,1993 chi square tests:all P-value >0.05 No evidence support the association of this variant with BD Negative
Parsian, A.,1995 case-control:p-value = 0.13; When using the transmitted allele relative risk approach, p-value = 0.04 Result suggested a association of this variant with BD Positive
Elvidge, G.,2001 Association analysis:chi square tests, chi-square=0.01, allele P-value = 0.92, 1 df.Meta analysis:odds ratio, OR, = 1.04; P-value = 0.60; 95% confidence interval, CI, = 0.89-1.20 No significant association was observed in BD. Negative

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)