Meta-analysis Report

Basic Info

Reference	Kishi, T.,2011(b) PMID: 20594600
Citation	Kishi, T., T. Okochi, et al. (2011). "Serotonin 1A receptor gene, schizophrenia and bipolar disorder: an association study and meta-analysis." Psychiatry Res 185(1-2): 20-26.
Disease Type	Bipolar Disorder & Schizophrenia
Study Type	Candidate-gene association study

Detail Info

Samples	For SZ,two studies including 2609 patients and 5731 controls;for BD,three studies including 3442 patients and 5870 controls
Statistic Method	Cochran's chi-square-based Q-statistic test was applied to assess between-study heterogeneity. The significance of the pooled odds ratio (OR) was determined using a Ztest.
Basic Result	Schizophrenia:We found significant heterogeneity among ORs (P(Q)=0.000142). The pooled OR derived from all studies comprising 965 patients and 1964 healthy control subjects did not indicate a significant association (random model: pooled OR=0.793, 95% CI=0.387-1.623, P(Z)=0.526). Bipolar disorder:We did not find significant heterogeneity among ORs (P(Q)=0.789). The pooled OR derived from all studies comprising 1148 patients and 1964 healthy control subjects indicated a significant association (fixed model: pooled OR=0.794, 95% CI=0.641-0.983, P(Z)=0.0344). No publication bias was found (t=0.656, p=0.536).We detected an association between rs6295 and BP,not SZ.

Genetic factors reported by this study for BD

SNPs reported by this study for BD (count: 2)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs6295	HTR1A	C>G		For BD, chi-square tests: genotype, P-value = 0.0116, corrected P-value = 0.139; allele, P-value = 0.00337, corrected P-value = 0.0404.Meta analysis: fixed model: pooled OR=0.794, 95% CI=0.641-0.983, P(Z)=0.0344).No publication bias was found (t=0.656, p=0.536).	Significant associations were found in both allele and genot...... Significant associations were found in both allele and genotype association. More...	Positive
rs878567	HTR1A	C>T		For BD, chi-square tests: genotype, P-value = 0.00000183, corrected P-value = 0.000022; allele, P-value = 0.00000212, corrected P-value = 0.0000254	Significant associations were found in both allele and genot...... Significant associations were found in both allele and genotype association. More...	Positive

Haplotypes reported by this study for BD (count: 2)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs6295 - rs878567	C-C	HTR1A	Haplotype analysis:likelihood ratio test:OR=1.38, 95%CI=1.19-1.59, individual P-value = 1.76E-05; global P-value = 2.03E-05, corrected global P-value = 2.44E-05 for BD	Significant association was found in both individual P-value...... Significant association was found in both individual P-value and global P-value in BD. More...	Positive
rs6295 - rs878567	G-C	HTR1A	Haplotype analysis:likelihood ratio test:OR=1.38, 95%CI=1.19-1.59, individual P-value = 1.76E-05; global P-value = 2.03E-05, corrected global P-value = 2.44E-05 for BD	Significant association was found in both individual P-value...... Significant association was found in both individual P-value and global P-value in BD. More...	Positive

Genes reported by this study for BD (count: 1)

Gene	Statistical Values/Author Comments	Result Category
HTR1A	HTR1A may play an important role in the pathophysiology of BP, but not schizophrenia in the Japanese...... HTR1A may play an important role in the pathophysiology of BP, but not schizophrenia in the Japanese population. More...	Positive

Genetic factors reported by this study for SZ and/or MDD

SNPs reported by this study for SZ/MDD

Disease	SNP	Related Gene(s)	Statistical Values	Description	Result Category
SZ	rs6295	HTR1A	For SZ, chi-square tests:genotype, P-value = 0.12;allele, P-value = 0.146;meta analysis:random model:pooled OR=0.793, 95% CI=0.387-1.623, P(Z)=0.526	No significant association was observed.	Negative
SZ	rs878567	HTR1A	For SZ, chi-square tests:genotype, P-value = 0.0606, corrected P-value = 0.286;allele, P-value = 0.0238	No significant association was observed.	Negative

Haplotypes reported by this study for SZ/MDD

Disease	Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Description	Result Category
SZ	rs6295 - rs878567	C-C	HTR1A	Haplotype analysis:likelihood ratio test:OR=1.20, 95%CI=0.971-1.47, individual P-value = 0.0921; global P-value = 0.0935	No significant association was observed in SZ.	Negative
SZ	rs6295 - rs878567	G-C	HTR1A	Haplotype analysis:likelihood ratio test:OR=1.20, 95%CI=0.971-1.47, individual P-value = 0.0921; global P-value = 0.0935	No significant association was observed in SZ.	Negative

Genes reported by this study for SZ/MDD

Disease	Gene	Description	Result Category
SZ	HTR1A	HTR1A may play an important role in the pathophysiology of BP, but not schizophrenia in the Japanese population.	Negative