BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Basic Info

Reference	Yang, S. Y., 2015 PMID: 26418860
Citation	Yang, S. Y., et al. (2015). "Association between ST8SIA2 and the Risk of Schizophrenia and Bipolar I Disorder across Diagnostic Boundaries." PLoS One 10(9): e0139413.
Disease Type	schizophrenia, bipolar disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	582 patients with schizophrenia, 339 patients with BD, 502 healthy controls
SNP/Region/Marker Size	34 SNPs
Predominant Ethnicity
Population	Korean
Gender	53.6% male for schizophrenia; 38.3% male for BD I; 25.2% male for BD II, 43.8% male for healthy controls
Age Group	adults : mean age (SD) = 33.9 (9.5) years for schizophrenia patients; mean age (SD) = 33.9 (10.1) years for BD I patients; mean age (SD) = 37.4 (11.4) years for BD II patients, mean age (SD) = 31.6 (7.9) years for controls

Detail Info

Sample Diagnosis	DSM-IV
Sample Status	Patients who met the DSM-IV diagnostic criteria for schizophrenia (n = 582) and BD (n = 339), including bipolar I disorder (BD-I) (n = 180) and bipolar II disorder (BD-II) (n = 159) were recruited from the inpatient unit and outpatient clinic of Samsung Medical Center and Seoul National University Bundang Hospital.
Technique	Multiplex SNP genotyping was performed by primer extension and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using the iPLEX Gold technology from Sequenom.
Statistical Method	We used the Kruskal-Wallis test or the chi-square test to reveal differences in demographic variables among the patient and control groups. The Hardy-Weinberg equilibriumwas checked with Fisherâ€™s exact test for the genetics analysis, and no significant deviation was observed in any of the SNPs.Genotype-wise association was evaluated by logistic regression analysis with age and sex as covariates.
Result Summary	We identified a possible role of ST8SIA2 in the common susceptibility of schizophrenia and BD-I. However, no association trend was observed for bipolar II disorder.

SNPs reported by this study for BD (count: 14)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs8025225	ST8SIA2			P-value=0.024,Â OR=0.519, 95%CI=0.294-0.916	BD-I showed nominally significant associations with rs375991...... BD-I showed nominally significant associations with rs3759915, rs4777969, rs11637898, rs4777980, rs8037133, and rs2168351 under the dominant and additive models, and with rs8025225 under the recessive model. More...	Positive
rs4777969	ST8SIA2			P-value=0.032,Â OR=0.682, 95%CI=0.480-0.968	BD-I showed nominally significant associations with rs375991...... BD-I showed nominally significant associations with rs3759915, rs4777969, rs11637898, rs4777980, rs8037133, and rs2168351 under the dominant and additive models, and with rs8025225 under the recessive model. More...	Positive
rs11637898	ST8SIA2			P-value=0.005,Â OR=1.641, 95%CI=1.162-2.319	The strongest association was observed in rs11637898 for sch...... The strongest association was observed in rs11637898 for schizophrenia (p = 0.0033) and BD-I (p = 0.0050) under the dominant model. More...	Positive
rs4777973	ST8SIA2			P-value=0.135,Â OR=1.311, 95%CI=0.919-1.871	BD-I showed nominally significant associations with rs375991...... BD-I showed nominally significant associations with rs3759915, rs4777969, rs11637898, rs4777980, rs8037133, and rs2168351 under the dominant and additive models, and with rs8025225 under the recessive model. More...	Negative
rs3784737	ST8SIA2 ENO1P2			P-value=0.343,Â OR=1.182, 95%CI=0.837-1.670	BD-I showed nominally significant associations with rs375991...... BD-I showed nominally significant associations with rs3759915, rs4777969, rs11637898, rs4777980, rs8037133, and rs2168351 under the dominant and additive models, and with rs8025225 under the recessive model. More...	Negative
rs4777980	ST8SIA2 ENO1P2			P-value=0.002,Â OR=1.729, 95%CI=1.215-2.459	BD-I showed nominally significant associations with rs375991...... BD-I showed nominally significant associations with rs3759915, rs4777969, rs11637898, rs4777980, rs8037133, and rs2168351 under the dominant and additive models, and with rs8025225 under the recessive model. More...	Positive
rs2168351	ST8SIA2			P-value=0.030,Â OR=1.483, 95%CI=1.038-2.120	BD-I showed nominally significant associations with rs375991...... BD-I showed nominally significant associations with rs3759915, rs4777969, rs11637898, rs4777980, rs8037133, and rs2168351 under the dominant and additive models, and with rs8025225 under the recessive model. More...	Positive
rs8037133	ST8SIA2			P-value=0.010,Â OR=1.591, 95%CI=1.117-2.264	BD-I showed nominally significant associations with rs375991...... BD-I showed nominally significant associations with rs3759915, rs4777969, rs11637898, rs4777980, rs8037133, and rs2168351 under the dominant and additive models, and with rs8025225 under the recessive model. More...	Positive
rs3759915	ST8SIA2			P-value=0.024,Â OR=1.609, 95%CI=1.065-2.430	BD-I showed nominally significant associations with rs375991...... BD-I showed nominally significant associations with rs3759915, rs4777969, rs11637898, rs4777980, rs8037133, and rs2168351 under the dominant and additive models, and with rs8025225 under the recessive model. More...	Positive
rs3784731	ST8SIA2			P-value=0.238,Â OR=1.231, 95%CI=0.871-1.739	BD-I showed nominally significant associations with rs375991...... BD-I showed nominally significant associations with rs3759915, rs4777969, rs11637898, rs4777980, rs8037133, and rs2168351 under the dominant and additive models, and with rs8025225 under the recessive model. More...	Negative
rs1455777	ST8SIA2			P-value=0.119,Â OR=1.318, 95%CI=0.932-1.865	BD-I showed nominally significant associations with rs375991...... BD-I showed nominally significant associations with rs3759915, rs4777969, rs11637898, rs4777980, rs8037133, and rs2168351 under the dominant and additive models, and with rs8025225 under the recessive model. More...	Negative
rs10775256	ST8SIA2			P-value=0.213,Â OR=0.708, 95%CI=0.410-1.220	BD-I showed nominally significant associations with rs375991...... BD-I showed nominally significant associations with rs3759915, rs4777969, rs11637898, rs4777980, rs8037133, and rs2168351 under the dominant and additive models, and with rs8025225 under the recessive model. More...	Negative
rs897463	ST8SIA2			P-value=0.259,Â OR=0.766, 95%CI=0.482-1.217	BD-I showed nominally significant associations with rs375991...... BD-I showed nominally significant associations with rs3759915, rs4777969, rs11637898, rs4777980, rs8037133, and rs2168351 under the dominant and additive models, and with rs8025225 under the recessive model. More...	Negative
rs7168443	ST8SIA2			P-value=0.431,Â OR=0.837, 95%CI=0.538-1.303	BD-I showed nominally significant associations with rs375991...... BD-I showed nominally significant associations with rs3759915, rs4777969, rs11637898, rs4777980, rs8037133, and rs2168351 under the dominant and additive models, and with rs8025225 under the recessive model. More...	Negative