Gene Report

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Basic Info

Approved Symbol	TRAPPC12
Previous Symbol	TTC15
Symbol Alias	CGI-87, TTC-15
Approved Name	trafficking protein particle complex 12
Previous Name	tetratricopeptide repeat domain 15
Location	2p25.3
Position	chr2:3379675-3485094, 1
External Links	HGNC: 24284 Entrez Gene: 51112 Ensembl: ENSG00000171853 UCSC: uc002qxm.1
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Georgi, B., 2014	SNP: rs11686212	Putative damaging exonic variant was found within this gene.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016192	vesicle-mediated transport	biological process	IEA	10
GO:0004175	endopeptidase activity	molecular function	IBA	8
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	cellular component	IEA	3
GO:0006508	proteolysis	biological process	IBA	34

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs11686212	chr2:3388524 - 3388524(1)	missense_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2p25.3-p25.1	chr2:0-12000000	1 (1/0/0)
2p25.3-25.1	chr2:0-12000000	1 (0/1/0)
2p25	chr2:0-12000000	3 (0/1/2)
Chr 2	chr2:0-242193529	3 (0/3/0)
2q13-q14_126.907cM	chr2:0-4500000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr2:3379675..3485094 View in gBrowse