Gene Report

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Basic Info

Approved Symbol	TCN1
Symbol Alias	TCI, TC1
Approved Name	transcobalamin I (vitamin B12 binding protein, R binder family)
Name Alias	haptocorin, "haptocorrin"
Location	11q11-q12
Position	chr11:59852800-59866575, -1
External Links	HGNC: 11652 Entrez Gene: 6947 Ensembl: ENSG00000134827 UCSC: uc001noj.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Hattori, E.,2009	SNP: rs1042613	After the two-stage analysis, markers in this gene remained nominally significant (allelic P<0.05) with the same allele being consistently over-represented in both the first and the follow-up stages.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005615	extracellular space	cellular component	IDA[16502470]	85
GO:0006767	water-soluble vitamin metabolic process	biological process	TAS	5
GO:0009235	cobalamin metabolic process	biological process	IBA; TAS	2
GO:0006824	cobalt ion transport	biological process	IEA	1
GO:0031419	cobalamin binding	molecular function	IBA	2
GO:0005576	extracellular region	cellular component	TAS	97
GO:0015889	cobalamin transport	biological process	IEA	1
GO:0006766	vitamin metabolic process	biological process	TAS	5
GO:0044281	small molecule metabolic process	biological process	TAS	117

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 4)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1042613	chr11:59855960 - 59855960(1)	downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; synonymous_variant; upstream_gene_variant	1(1/0/0)

rs_ID	Location	Functional Annotation
rs519221	chr11:59857063 - 59857063(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs537545	chr11:59868647 - 59868647(1)	upstream_gene_variant
rs557564	chr11:59861832 - 59861832(1)	intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
11q12.1	chr11:55800000-60100000	1 (0/0/1)
Chr 11	chr11:0-135086622	2 (0/2/0)
11q14.3-11q21	chr11:22000000-97400000	1 (0/0/1)
11p13-q13.3	chr11:31000000-70500000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr11:59852800..59866575 View in gBrowse