Gene Report

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Basic Info

Approved Symbol	NAV2
Symbol Alias	FLJ10633, FLJ11030, HELAD1, KIAA1419, POMFIL2, RAINB1, FLJ23707
Approved Name	neuron navigator 2
Name Alias	pore membrane and/or filament interacting like protein 2, "retinoic acid inducible gene in neuroblastoma 1", "helicase, APC down-regulated 1"
Location	11p15.1
Position	chr11:19350724-20121598, 1
External Links	HGNC: 15997 Entrez Gene: 89797 Ensembl: ENSG00000166833 UCSC: uc010rdm.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0027. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005614	interstitial matrix	cellular component	IEA	1
GO:0021564	vagus nerve development	biological process	IEA	1
GO:0021563	glossopharyngeal nerve development	biological process	IEA	1
GO:0008152	metabolic process	biological process	IEA	50
GO:0005524	ATP binding	molecular function	IEA	118
GO:0007608	sensory perception of smell	biological process	IEA	8
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0003025	regulation of systemic arterial blood pressure by baroreceptor feedback	biological process	IEA	1
GO:0007626	locomotory behavior	biological process	IEA	23
GO:0021554	optic nerve development	biological process	IEA	1
GO:0007605	sensory perception of sound	biological process	IEA	18
GO:0008201	heparin binding	molecular function	IEA	8
GO:0005515	protein binding	molecular function	IPI[16189514]	563
GO:0004386	helicase activity	molecular function	IEA	4

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
NAV2	PIAS2	NO	yeast 2-hybrid	16189514
NAV2	ING5	NO	yeast 2-hybrid	16189514
NAV2	RRAS	NO	in vitro	15031288

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 11	chr11:0-135086622	2 (0/2/0)
11p15	chr11:0-22000000	5 (0/4/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

Reference	Description	Category in MDD	Link in MK4MDD
21912391	genes significantly affected in female MDD subjects	Pos	NAV2

View in gBrowse

Region: chr11:19350724..20121598 View in gBrowse