BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

Search Gene with Disease Search Gene1 with Disease

Study Report

Comment on Study

View All Comments on Study

Basic Info

Reference	Nakata, K.,2003(b) PMID: 12951196
Citation	Nakata, K., H. Ujike, et al. (2003). "No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans." Neurosci Lett 349(3): 171-174.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	101 unrelated patients with BPD and 167 control subjects
SNP/Region/Marker Size	5 variants
Predominant Ethnicity	Mongloid
Population	Japanese
Gender	Male/female:53/48 for BPD patients and 85/82 for controls
Age Group	Adults : Mean age(SD)(year):52.2(14.1) for BPD patients and 46.1(11.8) for controls

Detail Info

Sample Diagnosis	DSM
Sample Status	The study subjects consisted of 101 unrelated patients with BPD, comprising 80 with bipolar I disorder and 21 with bipolar II disorder, and 167 control subjects. Control subjects were recruited mostly from the medical staff, and those with a positive personal or familial history of major psychiatric disorders were excluded from the control group. Patients were outpatients or inpatients in several psychiatric hospitals and Okayama University Graduate School of Medicine and Dentistry located in the middle-western area of Japan. Patients and controls were unrelated Japanese and individually matched for age, gender, and geographical origin.
Technique	genotyping
Statistical Method	chi-square test and Fisher's exact test
Result Summary	However, no significant associations were found between five polymorphisms of the DRP-2 gene (-975C>G, 352G>A, 426C>T, 1506T>C, and *2236T>C), and BPD, nor were associations detected between either of the polymorphisms and any subtype of BPD, bipolars I and II. The present study did not provide any evidence for a contribution of the DRP-2 gene to susceptibility to BPD.

Other variants reported by this study for BD (count: 5)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
DRP2 exon13 1506T>C	DRP2	point mutation	T>C		Association analysis:genotype P-value = 0.67, allele P-value = 0.38 for total BPD;genotype P-value = 0.5, allele P-value = 0.25 for total BPD-I;genotype P-value = 0.84, allele P-value = 0.86 for total BPD-II	No significant association was observed in BD. No significant association was observed in BD.	Negative
DRP2 exon14 *2236T>C	DRP2	point mutation	T>C		Association analysis:genotype P-value = 0.23, allele P-value = 0.2 for total BPD;genotype P-value = 0.43, allele P-value = 0.54 for total BPD-I;genotype P-value = 0.12, allele P-value = 0.06 for total BPD-II	No significant association was observed in BD. No significant association was observed in BD.	Negative
DRP2 exon4 352G>A	DRP2	point mutation	G>A		Association analysis:genotype P-value = 1, allele P-value = 0.64 for total BPD;genotype P-value = 1, allele P-value = 0.8 for total BPD-I;genotype P-value = 0.93, allele P-value = 0.72 for total BPD-II	No significant association was observed in BD. No significant association was observed in BD.	Negative
DRP2 exon4 426C>T	DRP2	point mutation	C>Y		Association analysis:genotype P-value = 0.27, allele P-value = 0.46 for total BPD;genotype P-value = 0.31, allele P-value = 0.52 for total BPD-I;genotype P-value = 0.59, allele P-value = 0.78 for total BPD-II	No significant association was observed in BD. No significant association was observed in BD.	Negative
DRP2 5'-flanking -975C>G	DRP2	point mutation	C>G		Association analysis:genotype P-value = 0.22, allele P-value = 0.38 for total BPD;genotype P-value = 0.5, allele P-value = 0.72 for total BPD-I;genotype P-value = 0.13, allele P-value = 0.16 for total BPD-II	No significant association was observed in BD. No significant association was observed in BD.	Negative

Genes reported by this study for BD (count: 1)