Gene Report

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Basic Info

Approved Symbol	ALDH9A1
Previous Symbol	ALDH7, ALDH4, ALDH9
Symbol Alias	E3
Approved Name	aldehyde dehydrogenase 9 family, member A1
Location	1q24.1
Position	chr1:165662216-165698863, -1
External Links	HGNC: 412 Entrez Gene: 223 Ensembl: ENSG00000143149 UCSC: uc001gdh.1
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Strauss, K. A., 2014	SNP: rs1143660	The associated SNP in this gene showed no significant association with BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004029	aldehyde dehydrogenase (NAD) activity	molecular function	IDA[2925663]	2
GO:0005829	cytosol	cellular component	TAS	223
GO:0001889	liver development	biological process	IEA	14
GO:0042136	neurotransmitter biosynthetic process	biological process	IDA[2925663]	10
GO:0051287	NAD binding	molecular function	IEA	2
GO:0004028	3-chloroallyl aldehyde dehydrogenase activity	molecular function	TAS	1
GO:0033737	1-pyrroline dehydrogenase activity	molecular function	IEA	1
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS	20
GO:0042445	hormone metabolic process	biological process	TAS[2925663]	4
GO:0045329	carnitine biosynthetic process	biological process	IEA; TAS	1
GO:0047105	4-trimethylammoniobutyraldehyde dehydrogenase activity	molecular function	IBA	1
GO:0042803	protein homodimerization activity	molecular function	IEA	71
GO:0001822	kidney development	biological process	IEA	13
GO:0006081	cellular aldehyde metabolic process	biological process	IDA[8645224]	1
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0019145	aminobutyraldehyde dehydrogenase activity	molecular function	IDA[2925663]	1
GO:0005737	cytoplasm	cellular component	TAS[2925663]	322
GO:0005739	mitochondrion	cellular component	IEA	75
GO:0043176	amine binding	molecular function	IEA	1
GO:0055114	oxidation-reduction process	biological process	IDA[2925663]	43

Gene related KEGG pathways (count: 15)

ID	Name	No. of Genes in BDgene
hsa00071	Fatty acid metabolism	3
hsa00220	Urea cycle and metabolism of amino groups	4
hsa00620	Pyruvate metabolism	2

ID	Name	No. of Genes in BDgene
hsa00053	Ascorbate and aldarate metabolism	2
hsa00120	Bile acid biosynthesis	6
hsa00561	Glycerolipid metabolism	6
hsa00641	3-Chloroacrylic acid degradation	2
hsa00640	Propanoate metabolism	2
hsa00310	Lysine degradation	2
hsa00280	Valine, leucine and isoleucine degradation	4
hsa00340	Histidine metabolism	6
hsa00650	Butanoate metabolism	7
hsa00410	beta-Alanine metabolism	4
hsa00380	Tryptophan metabolism	9
hsa00903	Limonene and pinene degradation	2

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1143660	chr1:165679473 - 165679473(1)	downstream_gene_variant; missense_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	1(0/1/0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Kember[2015]_3	chr1:165644865-165649715 (UCSC build 37, hg19)	4851		deletion

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1p32.1-q31.1	chr1:58500000-190800000	1 (0/1/0)
Chr 1	chr1:0-248956422	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr1:165662216..165698863 View in gBrowse