BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Basic Info

Name	TH intron 1 tetranucleotide repeat
Type	duplication
Location	intron 1
Related Gene	TH
No. of Study	5 (Positive: 0; Negative 5; Trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	YES

Variant related studies (count: 5)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Furlong, R. A.,1999(c)	multi-alleles		For bipolar vs. control: alleles, chi square = 5.50, 4 df, P-value = 0.24; genotypes, chi square = 17.08, 14 df, P-value = 0.25.For meta analysis:P-value>0.05.	No significant differences were found in bipolar groups.	Negative
Souery, D.,1996(a)	multi-alleles		Fisher's exact test:all P-value >0.05	No significant differences were found in bipolar groups.	Negative
Korner, J.,1994			the London (X² = 1.80, df = 4, P-value = 0.77), the Cardiff (X² = 2.04, df = 4, P-value = 0.73), or the Bonn study (X² = 7.34, df = 4, P-value = 0.12). There also was no significant difference when pooled data were analysed (X² = 1.69, P-value = 0.79).	No evidence support the association of this variant with BD	Negative
Souery, D.,1996(b)			Fisher's exact test:all P-value >0.05	No significant differences were found in bipolar groups.	Negative
Souery, D.,1999	multi-alleles		chi square tests:allele:chi square = 2.882; P-value = 0.578;genotype:chi square = 12.469; P-value = 0.569;Homo-hetero:chi square = 0.067; P-value = 0.796.	No significant differences were found in bipolar groups.	Negative

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 2)

Reference	Statistical Result	Description	Result Category
Souery, D.,1996(a)	Fisher's exact test:all P-value >0.05	No significant differences were found in unipolar groups.	Negative
Furlong, R. A.,1999(c)	For unipolar vs. control: alleles, chi squre = 4.33, 4 df, P-value = 0.36; genotypes, chi squre = 17.69, 14 df, P-value = 0.22;For meta analysis:P-value>0.05.	No significant differences were found in unipolar groups.	Negative