BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Other Variant Report

Basic Info

Name	TH 1-5 allele
Type	others
Related Gene	TH
No. of Study	1 (Positive: 0; Negative 1; Trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	YES

Variant related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Oruc, L., 1997 (a)			Fisherâ€™s exact test, P-value=0.76 for BPI, P-value=1 for BPI + UPR; Fisherâ€™s exact test, P-value=0.5 for BPI, P-value=0.26 for BPI + UPR; Fisherâ€™s exact test, P-value=0.38 for BPI, P-value=0.47 for BPI + UPR; Fisherâ€™s exact test, P-value=0.39 for BPI, P-value=0.72 for BPI + UPR; Fisherâ€™s exact test, P-value=0.88 for BPI, P-value=0.8 for BPI + UPR; Fisherâ€™s exact test, P-value=0.7 for BPI, P-value=0.72 for BPI + UPR; Fisherâ€™s exact test, P-value=0.08 for BPI, P-value=0.85 for BPI + UPR	For the TH polymorphism, the '1,2' genotype was more frequen..... More For the TH polymorphism, the '1,2' genotype was more frequently observed among controls than in the patient group. However, this P value does not remain significant after applying a Bonferroni correction for multiple testing. When considering only BPI or UPR patients who were positive for family history, no significant differences were observed, either. Less	Negative

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Oruc, L., 1997 (a)	Fisherâ€™s exact test, P-value=0.88 for UPR, P-value=1 for BPI + UPR; Fisherâ€™s exact test, P-value=0.32 for UPR, P-value=0.26 for BPI + UPR; Fisherâ€™s exact test, P-value=0.66 for UPR, P-value=0.47 for BPI + UPR; Fisherâ€™s exact test, P-value=1 for UPR, P-value=0.72 for BPI + UPR; Fisherâ€™s exact test, P-value=0.54 for UPR, P-value=0.8 for BPI + UPR; Fisherâ€™s exact test, P-value=0.79 for UPR, P-value=0.72 for BPI + UPR; Fisherâ€™s exact test, P-value=0.91 for UPR, P-value=0.85 for BPI + UPR	For the TH polymorphism, the '1,2' genotype was more frequently observed among controls than in the patient group. However, this P value does not remain significant after applying a Bonferroni correction for multiple testing. When considering only BPI or UPR patients who were positive for family history, no significant differences were observed, either.	Negative