BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Basic Info

Name	PIK3C3 -432C->T
Type	point mutation
Related Gene	PIK3C3
No. of Study	1 (Positive: 1; Negative 0; Trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Variant related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Stopkova, P., 2004 (a)	C/T		Allele frequency BD vs. CONT, O²=0.46, P-value = 0.50 in American, Allele frequency BD vs. CONT, O²=6.95, P-value = 0.008 in Czech	In the U.S. sample, there was no significant difference in t..... More In the U.S. sample, there was no significant difference in the allele distribution between control subjects and patients with SZ and BD. In the Czech Republic group of a cohort of bipolar patients from the Czech Republic, we did find a statistically significant difference in allele distribution. Less	Positive

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Stopkova, P., 2004 (a)	Allele frequency SZ vs. CONT, O²=1.31, P-value = 0.25 in American, Allele frequency SZ vs. CONT in Ashkenazi Jews, Fisher statistic=5.67, P-value = 0.02, Allele frequency SZ vs. CONT in Sephardic Jews, Fisher statistic=5.65, P-value = 0.02. Combined Ashkenazi and Sephardic sample SZ vs. CONT, Fisher statistic=12.81, P-value = 0.0003.	In the U.S. sample, there was no significant difference in the allele distribution between control subjects and patients with SZ and BD. A statistically significant difference in allele distribution was also detected in a cohort of patients with SZ from Israel.	Positive

Overlap with MDD from cross-disorder studies (count: 0)