BDgene

Other Variant Report

Basic Info
Name PIK3C3 -432C->T
Type point mutation
Related Gene PIK3C3
No. of Study 1 (Positive: 1; Negative 0; Trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO

Variant related studies (count: 1)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Stopkova, P., 2004 (a) C/T Allele frequency BD vs. CONT, O2=0.46, P-value = 0.50 in American, Allele frequency BD vs. CONT, O2=6.95, P-value = 0.008 in Czech
In the U.S. sample, there was no significant difference in t..... More
Positive

Overlap with SZ from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Stopkova, P., 2004 (a) Allele frequency SZ vs. CONT, O2=1.31, P-value = 0.25 in American, Allele frequency SZ vs. CONT in Ashkenazi Jews, Fisher statistic=5.67, P-value = 0.02, Allele frequency SZ vs. CONT in Sephardic Jews, Fisher statistic=5.65, P-value = 0.02. Combined Ashkenazi and Sephardic sample SZ vs. CONT, Fisher statistic=12.81, P-value = 0.0003. In the U.S. sample, there was no significant difference in the allele distribution between control subjects and patients with SZ and BD. A statistically significant difference in allele distribution was also detected in a cohort of patients with SZ from Israel. Positive

Overlap with MDD from cross-disorder studies (count: 0)