BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Basic Info

Name	MTHFR exon 7 A1298C
Type	SNP
Location	exon 7
Related Gene	MTHFR
No. of Study	1 (Positive: 1; Negative 0; Trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Variant related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Hu C.Y., 2014	A/C		White: C vs. A: OR=1.32, 95%CI=1.05-1.66, P-value=0.017; CC + AC vs. AA: OR=1.33, 95%CI=1.08-1.64, P-value=0.008; CC vs. AC + AA: OR=1.85, 95%CI=1.02-3.34, P-value=0.042; CC vs. AA: OR=2.03, 95%CI=1.07-2.86, P-value=0.031	Significant association was found between the MTHFR A1298C p..... More Significant association was found between the MTHFR A1298C polymorphism and BPD in all genetic models. Less	Positive

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Hu C.Y., 2014	All studies: C vs. A: OR=1.08, 95%CI=0.99-1.18, P-value=0.081; CC + AC vs. AA: OR=1.10, 95%CI=1.00-1.22, P-value=0.049; CC vs. AC + AA: OR=1.13, 95%CI=0.95-1.35, P-value=0.166; CC vs. AA: OR=1.18, 95%CI=0.97-1.44, P-value=0.104. white: C vs. A: OR=1.07, 95%CI=0.96-1.19, P-value=0.218; CC + AC vs. AA: OR=1.08, 95%CI=0.95-1.23, P-value=0.217; CC vs. AC + AA: OR=1.13, 95%CI=0.89-1.43, P-value=0.313; CC vs. AA: OR=1.17, 95%CI=0.90-1.51, P-value=0.239. Asian: C vs. A: OR=1.10, 95%CI=0.94-1.29, P-value=0.253; CC + AC vs. AA: OR=1.14, 95%CI=0.96-1.35, P-value=0.136; CC vs. AC + AA: OR=1.15, 95%CI=0.86-1.54, P-value=0.342; CC vs. AA: OR=1.23, 95%CI=0.86-1.76, P-value=0.265	MTHFR A1298C was significant associated with SZ.	Positive

Overlap with MDD from cross-disorder studies (count: 0)