BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Basic Info

Name	MTHFR exon 4 C677T
Type	SNP
Location	exon 4
Related Gene	MTHFR
No. of Study	1 (Positive: 1; Negative 0; Trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Variant related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Hu C.Y., 2014	C/T		All studies: T vs. C: OR=1.03, 95%CI=0.86-1.23, P-value=0.765; TT + CT vs. CC: OR=1.17, 95%CI=0.94-1.46, P-value=0.152; TT vs. CT + CC: OR=1.26, 95%CI=1.00-1.59, P-value=0.048; TT vs. CC: OR=1.30, 95%CI=0.96-1.76, P-value=0.092. white: T vs. C: OR=1.02, 95%CI=0.67-1.57, P-value=0.919; TT + CT vs. CC: OR=1.01, 95%CI=0.61-1,65, P-value=0.981; TT vs. CT + CC: OR=1.07, 95%CI=0.57-1.98, P-value=0.84; TT vs. CC: OR=1.05, 95%CI=0.49-2.24, P-value=0.909. Asian: T vs. C: OR=1.07, 95%CI=0.94-1.21, P-value=0.311; TT + CT vs. CC: OR=1.07, 95%CI=0.89-1.29, P-value=0.456; TT vs. CT + CC: OR=1.32, 95%CI=1.03-1.69, P-value=0.031; TT vs. CC: OR=1.28, 95%CI=0.97-1.69, P-value=0.081. African: T vs. C: OR=0.88, 95%CI=0.34-2.30, P-value=0.793; TT + CT vs. CC: OR=1.83, 95%CI=1.25-2.69, P-value=0.002; TT vs. CT + CC: OR=1.56, 95%CI=0.81-3.04, P-value=0.186; TT vs. CC: OR=1.97, 95%CI=0.99-3.92, P-value=0.054.	Subgroup analysis by ethnicity indicated that the significan..... More Subgroup analysis by ethnicity indicated that the significant association with BPD existed among Asian and African populations, but not for the white. Less	Positive

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Hu C.Y., 2014	All studies: T vs. C: OR=1.15, 95%CI=1.07-1.23, P-value=<0.001; TT + CT vs. CC: OR=1.14, 95%CI=1.05-1.24, P-value=0.001; TT vs. CT + CC: OR=1.34, 95%CI=1.18-1.53, P-value=<0.001; TT vs. CC: OR=1.33, 95%CI=1.15-1.54, P-value=<0.001. white: T vs. C: OR=1.07, 95%CI=0.98-1.16, P-value=0.141; TT + CT vs. CC: OR=1.07, 95%CI=0.96-1.18, P-value=0.217; TT vs. CT + CC: OR=1.13, 95%CI=0.95-1.36, P-value=0.17; TT vs. CC: OR=1.15, 95%CI=0.94-1.40, P-value=0.173. Asian: T vs. C: OR=1.21, 95%CI=1.08-1.34, P-value=0.001; TT + CT vs. CC: OR=1.22, 95%CI=1.07-1.38, P-value=0.003; TT vs. CT + CC: OR=1.50, 95%CI=1.26-1.78, P-value=<0.001; TT vs. CC: OR=1.46, 95%CI=1.19-1.78, P-value=<0.001. African: T vs. C: OR=2.14, 95%CI=1.42-3.23, P-value=<0.001; TT + CT vs. CC: OR=1.85, 95%CI=1.10-3.09, P-value=0.02; TT vs. CT + CC: OR=4.28, 95%CI=1.76-10.29, P-value=0.001; TT vs. CC: OR=4.67, 95%CI=1.89-11.57, P-value=0.001	Meta-analysis showed that MTHFR C677T was significantly associated with SZ.	Positive

Overlap with MDD from cross-disorder studies (count: 0)