BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Other Variant Report

Basic Info

Name	IMPA2 -461C>T
Type	point mutation
Related Gene	IMPA2
No. of Study	2 (Positive: 1; Negative 1; Trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Variant related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Sjoholt, G., 2004	C>T		P-value = 0.006, X²=7.579 in Palestinian Arabs families	The -461C and -207 T alleles were significantly more often t..... More The -461C and -207 T alleles were significantly more often transmitted than nontransmitted to bipolar offspring. No differences were found between paternal and maternal inheritance of the IMPA2 polymorphisms. Less	Positive
Dimitrova, A.,2005	C/T		Allelic association:P-value(TDT)=0.74 in BG trios;P-value(TDT)=0.34 in UK trios;P-value = 0.25 in UK case/control sample	No significant associations were found.	Negative

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)