BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Other Variant Report

Basic Info

Name	IMPA2 -207T>C
Type	point mutation
Related Gene	IMPA2
No. of Study	2 (Positive: 2; Negative 0; Trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Variant related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Ohnishi, T., 2007	T/C		Fisher's exact test, allelic P-value = 0.046, genotypic P-value = 0.114	allelic distributions differed significantly, albeit modest,..... More allelic distributions differed significantly, albeit modest, between bipolar patients and controls Less	Positive
Sjoholt, G., 2004	T>C		P-value = 0.002, X²=9.468 in Palestinian Arabs families	The -461C and -207 T alleles were significantly more often t..... More The -461C and -207 T alleles were significantly more often transmitted than nontransmitted to bipolar offspring. No differences were found between paternal and maternal inheritance of the IMPA2 polymorphisms. Less	Positive

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Ohnishi, T., 2007	Fisher's exact test, allelic P-value = 0.207, genotypic P-value = 0.294		Negative

Overlap with MDD from cross-disorder studies (count: 0)