BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Other Variant Report

Basic Info

Name	IMPA2 -185A>G
Type	point mutation
Related Gene	IMPA2
No. of Study	2 (Positive: 0; Negative 2; Trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Variant related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Ohnishi, T., 2007	G/A		Fisher's exact test, allelic P-value = 0.197, genotypic P-value = 0.184		Negative
Sjoholt, G., 2004	A>G		P-value = 0.05, X²=3.8 in Palestinian Arabs families	Two nearby polymorphisms in the IMPA2 promoter, -241_-237dup..... More Two nearby polymorphisms in the IMPA2 promoter, -241_-237dup and -185A>G, demonstrated a similar trend of association to bipolar disorder. No differences were found between paternal and maternal inheritance of the IMPA2 polymorphisms. Less	Negative

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Ohnishi, T., 2007	Fisher's exact test, allelic P-value = 0.507, genotypic P-value = 0.797		Negative

Overlap with MDD from cross-disorder studies (count: 0)