BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Other Variant Report

Basic Info

Name	HTR3B 547G>A (Val183Ile)
Type	point mutation
Related Gene	HTR3B
No. of Study	1 (Positive: 1; Negative 0; Trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Variant related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Frank, B., 2004	G>A		Genotypic P-value = 0.04. OR (95% CI)=8.5 (0.99-73.27); allelic P-value = 0.05, OR (95% CI)=8.02 (0.95-67.8) in the standard sample of bipolar affective patients (n=49) compared with controls (n=62)	Most of the tested SNPs did not reach statistical significan..... More Most of the tested SNPs did not reach statistical significance since there was no outstanding difference in allele and genotype distributions between the sample of patients with BPAD or SZ and the control sample Less	Positive

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Frank, B., 2004	Genotypic P-value = 0.63. OR (95% CI)=2.44 (0.25-24.05); allelic P-value = 0.63, OR (95% CI)=2.41 (0.25-23.48) in the schizophrenia patients (n=78) compared with controls (n=62)	Most of the tested SNPs did not reach statistical significance since there was no outstanding difference in allele and genotype distributions between the sample of patients with BPAD or SZ and the control sample	Negative

Overlap with MDD from cross-disorder studies (count: 0)