BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Basic Info

Name	HTR3B 5'UTR -102delAAG
Type	insertion/deletion
Location	5'UTR
Length of Repeat Unit	3bp
Related Gene	HTR3B
No. of Study	1 (Positive: 1; Negative 0; Trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Variant related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Frank, B., 2004			Genotypic P-value = 0.005. OR (95% CI)=0.17 (0.05-0.63); allelic P-value = 0.008, OR (95% CI)=0.2 (0.057-0.7) in the standard sample of bipolar affective patients (n=49) compared with controls (n=62). Genotypic P-value = 0.0076. OR (95% CI)=0.43 (0.23-0.78); allelic P-value = 0.0082, OR (95% CI)=0.47 (0.27-0.83) in the extended sample of bipolar affective patients (n=162) compared with German controls (n=100). Genotypic P-value = 0.005. OR (95% CI)=0.45 (0.26-0.77); allelic P-value = 0.006, OR (95% CI)=0.49 (0.3-0.82) in the extended sample of bipolar affective patients (n=162) compared with German controls (n=162).	The prevalence of the 3 bp deletion in the 5' UTR of HTR3B (..... More The prevalence of the 3 bp deletion in the 5' UTR of HTR3B ( -100_ -102delAAG) was much lower in patients with BPAD compared to controls. Less	Positive

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Frank, B., 2004	Genotypic P-value = 0.22. OR (95% CI)=0.58 (0.26-1.29); allelic P-value = 0.21, OR (95% CI)=0.62 (0.29-1.31) in the schizophrenia patients (n=78) compared with controls (n=62).	Most of the tested SNPs did not reach statistical significance since there was no outstanding difference in allele and genotype distributions between the sample of patients with BPAD or SZ and the control sample	Negative

Overlap with MDD from cross-disorder studies (count: 0)