BDgene

Other Variant Report

Basic Info
Name HTR3B 386A>C (Tyr129Ser)
Type point mutation
Related Gene HTR3B
No. of Study 1 (Positive: 1; Negative 0; Trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO

Variant related studies (count: 1)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Frank, B., 2004 A>C Genotypic P-value = 0.04 . OR (95% CI)=0.4 (0.17-0.93); allelic P-value = 0.05, OR (95% CI)=0.48 (0.22-1.02) in the standard sample of bipolar affective patients (n=49) compared with controls (n=62)
Most of the tested SNPs did not reach statistical significan..... More
Positive

Overlap with SZ from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Frank, B., 2004 Genotypic P-value = 0.87. OR (95% CI)=1.07 (0.55-2.1); allelic P-value = 0.87, OR (95% CI)=1.05 (0.59-1.87) in the schizophrenia patients (n=78) compared with controls (n=62) Most of the tested SNPs did not reach statistical significance since there was no outstanding difference in allele and genotype distributions between the sample of patients with BPAD or SZ and the control sample Negative

Overlap with MDD from cross-disorder studies (count: 0)