Study Report
Basic Info
| Reference |
Massat, I., 2007 PMID: 17767148
|
| Citation |
Massat, I., B. Lerer, et al. (2007). "HTR2C (cys23ser) polymorphism influences early onset in bipolar patients in a large European multicenter association study." Mol Psychiatry 12(9): 797-798.
|
| Disease Type |
Bipolar I Disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
625 BP patients and 829 controls |
| SNP/Region/Marker Size |
1 SNP |
| Predominant Ethnicity |
|
| Population |
European |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Sample Status |
the patients were recruited in eight collaborative centers (Athens, Bonn, Brussels, Edinburgh, Jerusalem, Milan, Sofia, Zagreb); 66 were early onset BP of 625 patients |
| Technique |
genotyping |
| Statistical Method |
logistic regression |
| Result Summary |
The Ser23 allele may be involved as a specific susceptibility gene in EO-BP phenotype or act as a modifier factor, contributing to influence AAO of the BP phenotype. |
Other variants reported by this study for BD (count: 1)
| Variant Name |
Related Gene |
Type |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| HTR2C Cys23Ser |
HTR2C |
point mutation |
|
|
P-value = 0.004, OR=2.1, 95%CI=1.3-3.4 in EO-BP patients compared to controls; P-value = 0.039, OR=1.7, 95%CI=1.02-2.9 in EO-BP patients compared to BP with AAO>16
|
A significant association emerged with an excess of HTR2C Se......
A significant association emerged with an excess of HTR2C Ser23 allele in EO-BP patients compared to controls and BP with AAO>16. No difference was shown between BP group with AAO>16 years and controls.
More...
|
Positive
|
Genes reported by this study for BD (count: 1)
| Gene |
Statistical Values/Author Comments |
Result Category |
| HTR2C |
The Ser23 allele may be involved as a specific susceptibility gene in EO-BP phenotype or act as a mo......
The Ser23 allele may be involved as a specific susceptibility gene in EO-BP phenotype or act as a modifier factor, contributing to influence AAO of the BP phenotype.
More...
|
Positive
|
