BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Khan, R. A., 2016 PMID: 26861727
Citation	Khan, R. A., et al. (2016). "Analysis of association between common variants in the SLCO6A1 gene with schizophrenia, bipolar disorder and major depressive disorder in the Han Chinese population." World J Biol Psychiatry 17(2): 140-146.
Disease Type	schizophrenia, bipolar disorder and major depressive disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	1,248 unrelated SCZ cases, 1,344 BPD cases, 1,056 unrelated MDD cases and 1,248 normal controls
SNP/Region/Marker Size	5 SNPs
Predominant Ethnicity	Han Chinese
Population	Shanghai in origin
Gender	845 males and 403 females for unrelated SCZ cases, 584 males and 760 females for BPD cases, 737 males and 319 females for unrelated MDD cases, 672 males and 576 females for normal controls.
Age Group	adults : mean age (SD) = 36.44(9.0) years for SCZ cases; mean age (SD) = 34.84(11.44) years for BD cases; mean age (SD) = 34.41(12.09) years for MDD cases

Detail Info

Sample Diagnosis	DSM-IV
Sample Status	The patients included in this study were out-patients or sometimes stable in-patients, who were from and living in Shanghai. All SCZ cases were paranoid schizophrenics with no history of depression or mania. The presence of lifetime experience of psychotic symptoms and mood-incongruent psychotic symptoms were 59.3 and 38.9%, respectively, in BPD cases. All MDD patients were selected on the basis of the following criteria: (i) at least two distinct episodes of MDD; and (ii) no sign of BD during the 2-year period after the onset of depression.
Technique	Genotyping was performed on all the selected SNPs using Sequenom MassARRAY matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALD-TOF) platform with iPLEX Gold chemistry (Sequenom, San Diego, CA, USA) using DNA isolated from peripheral leucocytes of blood samples.
Statistical Method	Statistical differences between the cases and controls regarding their allelic frequencies and genotype distribution, Hardyâ€“Weinberg equilibrium (HWE) tests, single-site analysis for SCZ, BPD and MDD, haplotype analysis and 1,000 permutation tests were accomplished using the online SHEsisPlus software.
Result Summary	We found no association of rs6878284 with SCZ. Furthermore, we found a statistically significant association of the rs7734060 genotype with MDD after correction in the Han Chinese population. This is the first study which reveals no association of rs6878284 with SCZ and also predicts that rs7734060 could be a risk locus for MDD in the Han Chinese population.

SNPs reported by this study for BD (count: 4)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs7734060	SLCO6A1	T/G		P-value=0.174,Â OR=0.92, 95%CI=0.816-1.037	All four SNPs showed no association with BPD. All four SNPs showed no association with BPD.	Negative
rs981988	SLCO6A1	G/A		P-value=0.223,Â OR=1.077, 95%CI=0.955-1.215	All four SNPs showed no association with BPD. All four SNPs showed no association with BPD.	Negative
rs6878284	SLCO6A1	C/T		P-value=0.49,Â OR=1.039, 95%CI=0.931-1.159	All four SNPs showed no association with BPD. All four SNPs showed no association with BPD.	Negative
rs2400795	SLCO6A1	C/T		P-value=0.428,Â OR=0.956, 95%CI=0.856-1.068	All four SNPs showed no association with BPD. All four SNPs showed no association with BPD.	Negative