Study Report
Basic Info
| Reference |
Wen, Z., 2016 PMID: 26828755
|
| Citation |
Wen, Z., et al. (2016). "Polymorphisms in NRGN are associated with schizophrenia, major depressive disorder and bipolar disorder in the Han Chinese population." J Affect Disord 194: 180-187.
|
| Disease Type |
major depressive disorder & Bipolar Disorder & Schizophrenia |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study, meta-analysis |
| Sample Size |
1248 schizophrenia cases, 1344 bipolar disorder cases, 1056 major depressive disorder cases, and 1248 healthy controls |
| SNP/Region/Marker Size |
3 SNPs |
| Predominant Ethnicity |
Han Chinese |
| Population |
Shanghai in origin |
| Gender |
845 males and 403 females for schizophrenia cases, 737 males and 319 females for major depressive disorder cases, 584 males and 760 females for bipolar disorder cases, 672 males and 576 females for normal controls |
| Age Group |
adults
:
mean age (SD) = 36.44(9.00) years for schizophrenia cases; mean age (SD) = 34.41(12.09) years for major depressive disorder cases; mean age (SD) = 38.84 (11.44) years for bipolar disorder cases, mean age (SD) = 30.62 (11.35) years for normal controls
|
Detail Info
| Sample Diagnosis |
DSM-IV |
| Sample Status |
All cases were of Han Chinese origin and lived in Shanghai, China. Patients were interviewed by two independent psychiatrists and diagnosed strictly according to Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-IV) based on Structured Clinical Interviewfor DSM-IV Axis 1 Disorders (SCID-1). |
| Technique |
SNPs were genotyped using iPLEX chemistry on a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer (MALDI–TOF-MS, named as MassARRAY system, manufactured by Sequenom, Inc.). |
| Statistical Method |
P values of allelic and genotypic tests were calibrated using Bonferroni correction, and those for haplotype analysis were done by false discovery rate, and were considered statistically significant if they were below 0.05. |
| Result Summary |
Our findings prove that NRGN is a shared susceptibility gene of schizophrenia, major depression and bipolar disorder in Han Chinese, and this might provide a new target for the diagnosis and treatment of these mental disorders. |
SNPs reported by this study for BD (count: 2)
| SNP |
Related Gene(s) |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| rs12278912 |
NRGN
|
A/G |
|
P-value=0.0512, OR=0.865, 95%CI=0.748–1.001
|
For bipolar disorder, rs7113041 and rs12278912 showed alleli......
For bipolar disorder, rs7113041 and rs12278912 showed allelic or genotypic association before Bonferroni correction. After Bonferroni correction, only rs7113041 remained associated with bipolar disorder.
More...
|
Negative
|
| rs7113041 |
VSIG2
NRGN
|
C/G |
|
P-value=0.0174, OR=1.194, 95%CI=1.032-1.383
|
For bipolar disorder, rs7113041 and rs12278912 showed alleli......
For bipolar disorder, rs7113041 and rs12278912 showed allelic or genotypic association before Bonferroni correction. After Bonferroni correction, only rs7113041 remained associated with bipolar disorder.
More...
|
Positive
|
Haplotypes reported by this study for BD (count: 1)
| Markers |
Haplotype |
Related Gene(s)/Region(s) |
Statistical Values |
Author Comments |
Result Category |
| rs7113041–rs12278912 |
G-A |
NRGN
|
P(unadj)-value=0.000405, Corrected P-value=0.000540, OR=0.758, 95%CI=0.650-0.884
|
It is particularly noticeable that one haplotype, GA, was si......
It is particularly noticeable that one haplotype, GA, was significantly associated with schizophrenia, major depressive disorder, and bipolar disorder. The global P values for them were 0.004, 0.014, and 0.001 respectively, implicating a common risk region in NRGN for major psychiatric disorders.
More...
|
Positive
|
