Study Report
Basic Info
| Reference |
Emamalizadeh, B., 2016 PMID: 26941103
|
| Citation |
Emamalizadeh, B., et al. (2016). "RIT2 Polymorphisms: Is There a Differential Association?" Mol Neurobiol.
|
| Disease Type |
Parkinson’s disease, autism, essential tremor, schizophrenia, bipolar disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
PD(N = 520), ET (N = 350), autism (N = 470), SCZ(N = 510), BPD (N = 440); 1000 healthy control subjects |
| SNP/Region/Marker Size |
2 SNPs |
| Predominant Ethnicity |
|
| Population |
Iranian |
Detail Info
| Sample Status |
For each disease group, the corresponding control group was selected based on the sex, age, and ethnicity of the patients |
| Technique |
genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method |
| Statistical Method |
Pearson’s X2 test was applied to test the significance of genotype distribution and allele frequency between patient and control groups. Odds ratio with 95 % confidence interval (CI) was estimated, and P value of less than 0.05 (two-tailed) was considered to be significant. The Hardy–Weinberg equilibrium test was performed using Fisher’s exact test. |
| Result Summary |
Significant association was observed between rs12456492 and two disorders, PD and ET, whereas rs16976358 was found to be associated with autism, SCZ, and BPD. Our findings are indicative of differential association between the RIT2 SNPs and different neurological disorders. |
SNPs reported by this study for BD (count: 2)
| SNP |
Related Gene(s) |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| rs12456492 |
RIT2
|
G/A |
|
Genotype test: P-value=0.43; Allele test: P-value=0.21, OR=1.13, 95%CI=0.94-1.38; additive model: P-value=0.218, OR=1.13, 95%CI=0.93-1.37; dominant model: P-value=0.213, OR=1.20, 95%CI=0.90-1.60; ressecive model: P-value=0.482, OR=1.13, 95%CI=0.80-1.60
|
No association was observed between the rs12456492 genotypes......
No association was observed between the rs12456492 genotypes or allele frequencies and autism, SCZ, and BPD. The association of rs12456492 with BPD was no significant under additive and recessive models.
More...
|
Negative
|
| rs16976358 |
LINC00907
RIT2
|
G/A |
|
Genotype test: P-value=0.001; Allele test: P-value=0.007, OR=1.43, 95%CI=1.10-1.87; additive model: P-value=0.007, OR=1.43, 95%CI=1.10-1.87; dominant model: P-value=0.057, OR=1.34, 95%CI=0.99-1.80; ressecive model: P-value=0.0004, OR=6.21, 95%CI=1.82-21.24
|
The genotype distribution and allele frequencies were signif......
The genotype distribution and allele frequencies were significantly different in rs16976358 between normal controls and patients with autism, SCZ, and BPD. The association of rs16976358 with autism,SCZ,and BPD was also significant under additive and recessive models.
More...
|
Positive
|
