BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Basic Info

Reference	Liu, Z., 2015 PMID: 26227907
Citation	Liu, Z., et al. (2015). "MAOA Variants and Genetic Susceptibility to Major Psychiatric Disorders." Mol Neurobiol.
Disease Type	schizophrenia, bipolar disorder, major depressive disorder
Study Type	Candidate-gene association study

Detail Info

Other variants reported by this study for BD (count: 5)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
uVNTR MAOA	MAOA				p>0.1	Our meta-analysis showed that the uVNTR is not associated wi...... Our meta-analysis showed that the uVNTR is not associated with SCZ, BPD, or MDD. More...	Negative
MAOA-CA MAOA	MAOA					In the BPD studies, we found marginally significant differen...... In the BPD studies, we found marginally significant differences between patients and controls in females for allele A2, A5, and A6 (all p<0.09).When the data was further subdivided by ethnicity, the associations for allele A2 and A6 became significant in femaleEuropeans (A2 allele, p=0.0013, OR=1.898; A6 allele, p=0.010, OR=0.695) but not the other subgroups. More...	Positive
rs1137070 c.1460 C/T	MAOA		C/T			Meta-analysis of rs1137070 on BPD is not available since the...... Meta-analysis of rs1137070 on BPD is not available since there is only one study, but the effect size in this BPD sample (OR=1.106 for T allele) is similar with the results in meta-analysis of MDD and SCZ. rs1137070 is significantly associated with broad psychiatric disorders in males, females and combined samples, with similar effect size between gender groups. More...	Positive
rs1799835 c.941 T/G	MAOA		T/G		p>0.1	No association was observed in either males or females for M...... No association was observed in either males or females for MDD, BPD, and SCZ (all p>0.1). More...	Negative
MAOA-VNTR MAOA	MAOA					We find no evidence of association with BPD on this locus in...... We find no evidence of association with BPD on this locus in either males (p=0.782, OR=1.059) or females (p=0.717, OR=1.053). The data were also subdivided by ethnicity, and no positive association was found in either populations. More...	Negative