Study Report
Basic Info
| Reference |
Atakhorrami, M., 2015 PMID: 26354101
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| Citation |
Atakhorrami, M., et al. (2015). "A genetic variant in CAMKK2 gene is possibly associated with increased risk of bipolar disorder." J Neural Transm (Vienna).
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| Disease Type |
Bipolar Disorder & Schizophrenia |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
500 schizophrenia patients, 500 bipolar patients and 500 healthy controls |
| SNP/Region/Marker Size |
1 SNP |
| Predominant Ethnicity |
|
| Population |
Iranian |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Sample Status |
The inclusion criteria were as the following: (1) All SZ and BP patients met the diagnostic criteria based on diagnostic and statistical manual of mental disorders, fourth edition (DSM-IV) and diagnosis was confirmed by a psychiatrist. (2) Controls were recruited from individuals free of psychiatric disorders, drug abuse, alcohol dependence or brain injury at the time of examination. (3) Patients with psychiatric disorders except schizophrenia and bipolar disorder, alcohol dependence and brain trauma at the time of examination were also excluded from the study. Meanwhile, first-episode patients were excluded since diagnosis during that time is often unreliable. Individuals with a history of psychiatric disorders in family were also excluded from control group. |
| Technique |
PCR–RFLP (polymerase chain reaction-restriction fragment length polymorphism) |
| Result Summary |
For the first time, we showed that rs1063843 is highly associated with bipolar disorder, although more replication studies are needed to confirm our findings. |
SNPs reported by this study for BD (count: 1)
| SNP |
Related Gene(s) |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| rs1063843 |
CAMKK2
|
C/T |
T |
P-value < 0.001, OR=1.39, 95%CI=1.16-1.67 for bipolar vs normal; P-value=1, OR=1, 95%CI=0.83-1.2 for bipolar vs schizophrenia; P-value < 0.01, OR=1.4, 95%CI=1.16-1.68 for bipolar vs normal under additive model; P-value < 0.01, OR=2.17, 95%CI=1.46-3.22 for bipolar vs normal under recessive model
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The genotypes distribution and allele frequencies were signi......
The genotypes distribution and allele frequencies were significantly different between normal controls and both schizophrenia and bipolar patients, where T allele was found to be a risk factor for both schizophrenia and bipolar disorder. No difference was seen between schizophrenia and bipolar patients regarding to the genotype and allele frequencies. The genotype differences between normal and patient groups were significant under all three analyzed genetic models.
More...
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Positive
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