BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Ni, P., 2015 PMID: 26117066
Citation	Ni, P., et al. (2015). "Methionine sulfoxide reductase A (MsrA) associated with bipolar I disorder and executive functions in A Han Chinese population." J Affect Disord 184: 235-238.
Disease Type	Bipolar I Disorder
Study Design	case-control
Study Type	candidate-gene association study
Sample Size	375 BDI outpatients and 475 controls
SNP/Region/Marker Size	44 SNPs
Predominant Ethnicity	Mongloid
Population	Han Chinese
Gender	case: 169 men and 206 women; control: 236 men and 239 women
Age Group	adults : mean age=31.58, sd=11.46 years old of cases, control: 32.97, sd=12.89 years old

Detail Info

Sample Diagnosis	DSM-IV
Sample Status	A total of 375 BDI outpatients were recruited from Guangzhou Brain Hospital. Age at onset was 24.32 (SD=8.88) years, and 64.5% BDI patients had psychotic symptoms (delusions or hallucination).
Technique	genotyping
Statistical Method	Quantitative variables were analyzed using Student's t test, and categorical variables employing chi-square test with the SPSS software. Minor allele frequency (MAF) and Hardy Weinberg equilibrium (HWE) were calculated using Plink 1.07; the linkage disequilibrium structure was assessed by Haploview 4.2. In order to correct for multiple testing, P values from linear models were calculated by running 10,000 permutations.
Result Summary	Allele frequencies of the rs4840463 polymorphism were significantly different between BD I patients and controls, and between patients with psychotic symptoms and controls. BD I patients performed more poorly in 11 of the 13 neurocognitive measurements compared with controls. Three MsrA haplotypes showed significant associations with different executive functions. The limited sample size requires a cautious conclusion, and further comprehensive approaches are needed to explore the mechanism of MsrA's effect on BD I. The rs4840463 polymorphism in the MsrA gene may be associated with the increased risk of BD I in a Chinese population. The association of MsrA haplotypes with executive functions indicated that MsrA is associated with executive function defects in BD I patients.

SNPs reported by this study for BD (count: 4)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs6988046	MSRA MsrA			OR=0.7259, P-value=0.039	It had significantly different allele frequencies between BD...... It had significantly different allele frequencies between BDI patients and controls. More...	Positive
rs4840463	MSRA MsrA	C/A		OR=0.6477, P-value=0.006	It had significantly different allele frequencies between BD...... It had significantly different allele frequencies between BDI patients and controls. Meanwhile, allele frequencies of the rs4840463 polymorphism were significantly different between BDI patients with psychotic symptoms and controls. More...	Positive
rs814422	MSRA MsrA			OR=0.7361, P-value=0.048	It had significantly different allele frequencies between BD...... It had significantly different allele frequencies between BDI patients and controls. More...	Positive
rs6981546	MSRA MsrA			OR=0.7349, P-value=0.044	It had significantly different allele frequencies between BD...... It had significantly different allele frequencies between BDI patients and controls. More...	Positive

Genes reported by this study for BD (count: 1)