Study Report
Basic Info
| Reference |
Colasanti, A.,2013 PMID: 23942012
|
| Citation |
Colasanti, A., Owen, D.R., Grozeva, D., Rabiner, E.A., Matthews, P.M., Craddock, N., Young, A.H., 2013. Bipolar Disorder is associated with the rs6971 polymorphism in the gene encoding 18kDa Translocator Protein (TSPO). Psychoneuroendocrinology.
|
| Disease Type |
bipolar disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
1868 BD cases and 2938 controls for WTCCC dataset;7481 cases and 9250 controls for PGC dataset |
| SNP/Region/Marker Size |
1 SNP |
| Predominant Ethnicity |
Caucasian |
| Population |
WTCCC and PGC dataset |
Detail Info
| Statistical Method |
imputation-based analysis |
| Result Summary |
We report a nominal association between this TSPO polymorphism and the diagnosis of Bipolar Disorder in both the genome-wide dataset of the Wellcome Trust Case-Control Consortium and the Psychiatric Genome-Wide Association Study Consortium Bipolar Disorder group (OR=1.11, p=0.007; OR=1.10, p=0.011, respectively). We propose that the amino acid substitution affects hypothalamic-pituitary-adrenal (HPA) regulation, and hence may predispose to Bipolar Disorder. This supports the hypothesis that HPA dysregulation has a causal role in Bipolar Disorder, and is not just a consequence of the disease. |
SNPs reported by this study for BD (count: 1)
| SNP |
Related Gene(s) |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| rs6971 |
TSPO
TTLL12
|
|
|
allelic association : OR = 1.11, p = 0.007 for WTCCC dataset; OR = 1.10,p = 0.011 for PGC dataset
|
We report a nominal association between this TSPO polymorphi......
We report a nominal association between this TSPO polymorphism and the diagnosis of Bipolar Disorder.
More...
|
Positive
|
Genes reported by this study for BD (count: 1)
| Gene |
Statistical Values/Author Comments |
Result Category |
| TSPO |
We report a nominal association between this TSPO polymorphism and the diagnosis of Bipolar Disorder......
We report a nominal association between this TSPO polymorphism and the diagnosis of Bipolar Disorder. This supports the hypothesis that HPA dysregulation has a causal role in Bipolar Disorder, and is not just a consequence of the disease.
More...
|
Positive
|
