Meta-analysis Report
Basic Info
| Reference |
Rubinsztein, D. C.,1996 PMID: 8776592
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| Citation |
Rubinsztein, D. C., J. Leggo, et al. (1996). "Genetic association between monoamine oxidase A microsatellite and RFLP alleles and bipolar affective disorder: analysis and meta-analysis." Hum Mol Genet 5(6): 779-782.
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| Disease Type |
Bipolar Disorder |
| Study Type |
Candidate-gene association study |
Detail Info
| Samples |
Three studies with 67 males and 113 females with bipolar affective disorder and a similar number of matched controls. |
| Statistic Method |
Statistics were performed using the SPSS/PC+ software package (SSPC, Chicago, Ill.) |
| Basic Result |
In order to resolve these differences, we have examined this locus in our series of unrelated bipolar cases and age- and sex-matched controls and found significantly different MAOA microsatellite allele frequencies. In addition, we have pooled the data from the two previous UK studies with ours to create a total data set including 67 males and 113 females with bipolar affective disorder and a similar number of matched controls. No evidence for heterogeneity was observed for the control MAOA microsatellite or RFLP allele frequencies in these three studies. However, we found a significant difference between the pooled normal and bipolar allele frequencies both for the microsatellite and the RFLP at MAOA. |
Other variants reported by this study for BD (count: 2)
| Variant Name |
Related Gene |
Type |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| MAOA RFLP |
MAOA |
point mutation |
|
|
chi square = 8.08, 1 d.f., p = 0.0045
|
We found a significant difference between the pooled normal ......
We found a significant difference between the pooled normal and bipolar allele frequencies both for the RFLP at MAOA.
More...
|
Positive
|
| MAOA (CA)n |
MAOA |
microsatellite |
multi-alleles |
|
chi square = 13.8, 3 d.f., p = 0.003
|
We found a significant difference between the pooled normal ......
We found a significant difference between the pooled normal and bipolar allele frequencies both for the microsatellite at MAOA.
More...
|
Positive
|
Genes reported by this study for BD (count: 1)
| Gene |
Statistical Values/Author Comments |
Result Category |
| MAOA |
We found a significant difference between the pooled normal and bipolar allele frequencies both for ......
We found a significant difference between the pooled normal and bipolar allele frequencies both for the microsatellite and the RFLP at MAOA.
More...
|
Positive
|
