BDgene

Study Report

Basic Info
Reference
Citation Fanous, A. H., F. A. Middleton, et al. (2012). "Genetic overlap of schizophrenia and bipolar disorder in a high-density linkage survey in the Portuguese Island population." Am J Med Genet B Neuropsychiatr Genet 159B(4): 383-391.
Disease Type Bipolar Disorder & Schizophrenia
Study Design pedigree
Study Type Genome-wide Linkage Study
Sample Size 52 BD, 44 SZ, and 90 PSY total genotyped sibling pairs, respectively,from 47 families
SNP/Region/Marker Size 58,624 SNPs
Predominant Ethnicity
Population American

Detail Info

Genetic factors reported by this study for BD
Regions reported by this study for BD (count: 13)

Genetic factors reported by this study for SZ and/or MDD
Regions reported by this study for SZ/MDD
Disease Region Name Statistical Values Description Result Category
SZ 2p16.1 Linkage analysis: Maximum NPL (nearest maximum LOD) = -0.64 No significant linkage was found in this region. Negative
SZ 3q26.1-3q26.2 Linkage analysis: Maximum NPL (nearest maximum LOD) = 3.17(1.52) No significant linkage was found in this region. Negative
SZ 20p12.1 Linkage analysis: Maximum NPL (nearest maximum LOD) = 0.73 No significant linkage was found in this region. Negative
SZ 2p14-2p13.2 Linkage analysis: Maximum NPL (nearest maximum LOD) = -0.57 No significant linkage was found in this region. Negative
SZ 6q14.1 Linkage analysis: Maximum NPL (nearest maximum LOD) = 2.24 No significant linkage was found in this region. Negative
SZ 6q21 Linkage analysis: Maximum NPL (nearest maximum LOD) = 3.15(2.28) No significant linkage was found in this region. Negative
SZ 5q32 Linkage analysis: Maximum NPL (nearest maximum LOD) = 3.18(3.08) Suggestive linkage was found in this region. Trend
SZ 5q32-5q33.3 Linkage analysis: Maximum NPL (nearest maximum LOD) = 3.18(2.29) Suggestive linkage was found in this region. Trend
SZ 6q22.1-6q22.33 Linkage analysis: Maximum NPL (nearest maximum LOD) = -0.47 No significant linkage was found in this region. Negative
SZ 11q14.3-11q21 Linkage analysis: Maximum NPL (nearest maximum LOD) = 1.26 No significant linkage was found in this region. Negative
SZ 11q14.1 Linkage analysis: Maximum NPL (nearest maximum LOD) = 0.58 No significant linkage was found in this region. Negative
SZ 1p13.2-1q21.3 Linkage analysis: Maximum NPL (nearest maximum LOD) = -0.37 No significant linkage was found in this region. Negative
SZ 16q23.3 Linkage analysis: Maximum NPL (nearest maximum LOD) = -0.33 No significant linkage was found in this region. Negative