Study Report
Basic Info
| Reference |
Buttenschon, H. N., 2004 PMID: 14681919
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| Citation |
Buttenschon, H. N., O. Mors, et al. (2004). "No association between a neuronal nitric oxide synthase (NOS1) gene polymorphism on chromosome 12q24 and bipolar disorder." Am J Med Genet B Neuropsychiatr Genet 124B(1): 73-75.
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| Disease Type |
Bipolar Disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
The Danish sample included 83 patients with bipolar affective disorder and 120 controls. The British sample consisted of 286 bipolar type I and II cases and 316 controls. |
| SNP/Region/Marker Size |
1 SNP |
| Predominant Ethnicity |
Caucasian |
| Population |
Danish and British |
| Age Group |
adults
:
Only patients with an age of onset before 35 years were included.
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Detail Info
| Sample Diagnosis |
DSM-IV and ICD-10 or Research Diagnostic Criteria |
| Technique |
PCR and genotyping |
| Statistical Method |
Association of SNPs with bipolar disorder was analyzed for allelic and genotypic association using Chi-square analysis and Fisher's exact test. The Danish cases, the Danish controls, the British cases and the British controls were in Hardy-Weinberg equilibrium (P-values 0.16, 0.29, 0.44, 0.48, respectively). |
| Result Summary |
The allele and genotype frequencies were very similaramongcases and controls in the total and in the British sample. In the Danish sample, the genotype-wise P-value was 0.045. It is still possible that other polymorphisms in the NOS1 gene could have a role in the genetic susceptibility to schizophrenia or bipolar disorder. |
SNPs reported by this study for BD (count: 1)
| SNP |
Related Gene(s) |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| rs2682826 |
NOS1
|
C/T |
|
Chi-square test or Fisher's exact test, allelic P-value = 0.137, genotypic P-value = 0.276 in total samples; allelic P-value = 0.105, genotypic P-value = 0.209 in British sample; allelic P-value = 0.980, genotypic P-value = 0.045 in Danish sample.
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The allele and genotype frequencies were very similaramongca......
The allele and genotype frequencies were very similaramongcases and controls in the total and in the British sample. In the Danish sample, we believe that the slight difference in genotype frequencies is due to chance.
More...
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Positive
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Genes reported by this study for BD (count: 1)
| Gene |
Statistical Values/Author Comments |
Result Category |
| NOS1 |
rs2682826, allelic P-value = 0.980, genotypic P-value = 0.045 in Danish sample..
The allele and genotype frequencies were very similaramongcases and controls in the total and in the......
The allele and genotype frequencies were very similaramongcases and controls in the total and in the British sample. In the Danish sample, we believe that the slight difference in genotype frequencies is due to chance. it is still possible that other polymorphisms in the NOS1 gene could have a role in the genetic susceptibility to schizophrenia or bipolar disorder.
More...
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Positive
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