BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Lin, Y. M., 2008 PMID: 18501009
Citation	Lin, Y. M., F. Davamani, et al. (2008). "Association analysis of monoamine oxidase A gene and bipolar affective disorder in Han Chinese." Behav Brain Funct 4: 21.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	108 BD and 103 controls
SNP/Region/Marker Size	2 markers
Predominant Ethnicity	Mongloid
Population	Han Chinese
Gender	BD patients (59 males and 49 females), healthy controls (55 males and 48 females)

Detail Info

Sample Diagnosis	DSM-IV
Sample Status	Only one patient was found to have co-morbid psychiatric condition with alcohol abuse, about 10% of the patients have medical problems like hypertension or diabetes.
Technique	PCR and genotyping
Statistical Method	Allelic distributions between patients and matched controls were analyzed using the X² test and Fisher's exact test. For allelic distributions analysis, MAOA-CA and -uVNTR polymorphisms were grouped into several classes to minimize the allele number. In addition, the linkage disequilibrium estimation (LD) and haplotypes construction using the expectation-maximization (EM) method were performed in female groups. Odds ratio and power estimation were estimated using SAS and Power Analysis and Sample Size (PASS) 2005 software (NCSS, Kaysville, UT, USA), respectively. The significance level for all statistical tests was 0.05 and we applied Bonferroni corrections for multiple tests in the association study.
Result Summary	While no difference in allelic distributions of two MAOA polymorphisms was found, the risk haplotype 114S was associated with BPD in male patients (P = 0.03). The significance, however, was not found in female patients with 114S haplotype.

Other variants reported by this study for BD (count: 2)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
MAOA promoter VNTR	MAOA	VNTR			not given in the original text	No differences were observed in single alleles or global dis...... No differences were observed in single alleles or global distributions of MAOA-CA and -uVNTR. More...	Negative
MAOA (CA)n	MAOA	microsatellite			not given in the original text	No differences were observed in single alleles or global dis...... No differences were observed in single alleles or global distributions of MAOA-CA and -uVNTR. More...	Negative