Study Report
Basic Info
| Reference |
Liu, C.,2001 PMID: 11378853
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| Citation |
Liu, C., J. A. Badner, et al. (2001). "Fine mapping supports previous linkage evidence for a bipolar disorder susceptibility locus on 13q32." Am J Med Genet 105(4): 375-380.
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| Disease Type |
Bipolar Disorder |
| Study Design |
pedigree |
| Study Type |
Candidate-region linkage study |
| Sample Size |
371 individuals from 22 multiplex pedigrees |
| SNP/Region/Marker Size |
16 microsatellite markers on 13q32 |
| Predominant Ethnicity |
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| Population |
NIMH collections |
Detail Info
| Statistical Method |
Two models of the affected phenotype were used in linkage analysis: Affection Status Model I (ASM I) that includes bipolar I, bipolar II with major depression, and schizoaffective disorder; and Affection Status Model II (ASM II) that includes ASM I and is broadened to include persons with two or more episodes of major depression with impairment.ASPEX was used for nonparametric multipoint and single-point linkage analysis. |
| Result Summary |
The strongest linkage evidence was detected by multipoint linkage analysis (ASPEX program) around D13S779-D13S225 with maximum LOD score of 3.25 under Affection Status Model II (ASM II; P = 0.0000546). Data from additional nine markers resulted in a decrease of the 95% confidence interval of the linkage region. Association analyses with GASSOC TDT and ASPEX/sib_tdt detect potential linkage disequilibrium with several markers, including D13S280 (ASPEX TDT P = 0.0033, ASM I). These data generated using a higher marker density within the proposed susceptibility region strengthen the validity of our previous findings and suggest a finer localization of the susceptibility gene(s) on 13q32. |
Regions reported by this study for BD (count: 1)
| Region |
Statistical Values |
Author Comments |
Result Category |
| 13q32 |
Nonparametric Single-Point Linkage Analyses: For marker D13S1252, ASM I , LOD = 2.31, P-value = 0.00055; ASM II, LOD = 2.58, P-value = 0.00028; For marker D13S1271, ASM I , LOD = 2.7, P-value = 0.00021; ASM II, LOD = 2.54, P-value = 0.00031
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Suggestive linkage was found in this region.
Suggestive linkage was found in this region.
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Trend
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