BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Basic Info

Reference	Schulze, T. G.,2004 PMID: 15219468
Citation	Schulze, T. G., S. Buervenich, et al. (2004). "Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees." Biol Psychiatry 56(1): 18-23.
Disease Type	Bipolar Disorder
Study Design	pedigree
Study Type	Candidate-region linkage study
Sample Size	Members of 245 families ascertained through a sibling pair affected with bipolar I or schizoaffective-bipolar disorder
SNP/Region/Marker Size	18 microsatellite markers spanning chromosome 6.
Predominant Ethnicity
Population	NIMH collections

Detail Info

Regions reported by this study for BD (count: 17)

Region	Statistical Values	Author Comments	Result Category
6q12	Affected Sibling-Pair Linkage Analysis: Paternal LOD = 0, Maternal LOD = 0, Gender-Combined LOD = 0	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
6q14.1	Affected Sibling-Pair Linkage Analysis: Paternal LOD = 0, Maternal LOD = 0, Gender-Combined LOD = 0	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
6p23	Affected Sibling-Pair Linkage Analysis: Paternal LOD = 0, Maternal LOD = 0, Gender-Combined LOD = 0	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
6p25.1	Affected Sibling-Pair Linkage Analysis: Paternal LOD = -0.03, Maternal LOD = 0.04, Gender-Combined LOD = 0	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
6q21	Affected Sibling-Pair Linkage Analysis: Paternal LOD = 0.33, Maternal LOD = 1.92, Gender-Combined LOD = 1.98	Suggestive linkage was found in this region. Suggestive linkage was found in this region.	Trend
6q23.1	Affected Sibling-Pair Linkage Analysis: Paternal LOD = 0.14, Maternal LOD = 0.28, Gender-Combined LOD = 0.37	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
6q16.1	Affected Sibling-Pair Linkage Analysis: Paternal LOD = 0.11, Maternal LOD = 0.86, Gender-Combined LOD = 0.86	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
6q16.3	Affected Sibling-Pair Linkage Analysis: Paternal LOD = 0.57, Maternal LOD = 2.86, Gender-Combined LOD = 3.05	Suggestive linkage was found in this region. Suggestive linkage was found in this region.	Trend
6p21.2	Affected Sibling-Pair Linkage Analysis: Paternal LOD = 0.09, Maternal LOD = 0.32, Gender-Combined LOD = 0.37	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
6p22.2	Affected Sibling-Pair Linkage Analysis: Paternal LOD = 0, Maternal LOD = 1.16, Gender-Combined LOD = 1.04	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
6p12.3	Affected Sibling-Pair Linkage Analysis: Paternal LOD = 0, Maternal LOD = 0, Gender-Combined LOD = 0	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
6p21.1	Affected Sibling-Pair Linkage Analysis: Paternal LOD = 0.01, Maternal LOD = 0.14, Gender-Combined LOD = 0.13	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
6q24.3	Affected Sibling-Pair Linkage Analysis: Paternal LOD = 0.29, Maternal LOD = 0.05, Gender-Combined LOD = 0.3	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
6q23.3	Affected Sibling-Pair Linkage Analysis: Paternal LOD = 0.07, Maternal LOD = -0.01, Gender-Combined LOD = 0.05	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
6q25.3	Affected Sibling-Pair Linkage Analysis: Paternal LOD = 0, Maternal LOD = 0, Gender-Combined LOD = 0	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
6q25.2	Affected Sibling-Pair Linkage Analysis: Paternal LOD = 0, Maternal LOD = 0, Gender-Combined LOD = 0	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
6q26	Affected Sibling-Pair Linkage Analysis: Paternal LOD = 0, Maternal LOD = 0, Gender-Combined LOD = 0	No significant linkage was found in this region. No significant linkage was found in this region.	Negative