BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Ferraren, D. O.,2005 PMID: 15635705
Citation	Ferraren, D. O., C. Liu, et al. (2005). "Linkage disequilibrium analysis in the LOC93081-KDELC1-BIVM region on 13q in bipolar disorder." Am J Med Genet B Neuropsychiatr Genet 133B(1): 12-17.
Disease Type	Bipolar Disorder
Study Design	family-based and case-control
Study Type	Candidate-gene association study
Sample Size	12"quads"(an affected sib pair and two genotyped parents) and seven trios(CNG);72 quads and 28 trios (NIMH);278 cases and 277 controls for association study
SNP/Region/Marker Size	10 SNPs
Predominant Ethnicity
Population	NIMH collections(Waves 1, 2, and 3) and CNG pedigree set

Detail Info

SNPs reported by this study for BD (count: 9)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs1408047	BIVM BIVM-ERCC5		C	Assocaition study: TDT P-value = 1 for CNG Series, TDT P-value = 0.15 for NIMH 1 and 2; chi quare test P-value > 0.05 in case-control study	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs1047740	KDELC1 BIVM		A	Assocaition study: TDT P-value = 0.4 for CNG Series, TDT P-value = 0.6 for NIMH 1 and 2; chi quare test P-value > 0.05 in case-control study	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs2274389	BIVM BIVM-ERCC5		A	Assocaition study: TDT P-value = 1 for CNG Series, TDT P-value = 0.41 for NIMH 1 and 2; chi quare test P-value > 0.05 in case-control study	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs1571069	BIVM BIVM-ERCC5		A	Assocaition study: TDT P-value = 1 for CNG Series, TDT P-value = 0.2 for NIMH 1 and 2; chi quare test P-value > 0.05 in case-control study	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs2281886	BIVM BIVM-ERCC5		C	Assocaition study: TDT P-value = 1 for CNG Series, TDT P-value = 0.26 for NIMH 1 and 2; chi quare test P-value > 0.05 in case-control study	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs2281885	BIVM BIVM-ERCC5		A	Assocaition study: TDT P-value = 0.52 for CNG Series, TDT P-value = 0.66 for NIMH 1 and 2; chi quare test P-value > 0.05 in case-control study	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs4743	ERCC5 BIVM BIVM-ERCC5		C	Assocaition study: TDT P-value = 0.36 for CNG Series, TDT P-value = 0.43 for NIMH 1 and 2; chi quare test P-value > 0.05 in case-control study	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs2296147	ERCC5 BIVM BIVM-ERCC5		C	Assocaition study: TDT P-value = 0.9 for CNG Series, TDT P-value = 0.44 for NIMH 1 and 2; chi quare test P-value > 0.05 in case-control study	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs8054	TEX30		C	Assocaition study: TDT P-value = 0.38 for CNG Series, TDT P-value = 0.7 for NIMH 1 and 2; chi quare test P-value > 0.05 in case-control study	No significant association was observed in BD. No significant association was observed in BD.	Negative

Haplotypes reported by this study for BD (count: 1)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs8054 - rs1047740 - rs2181675 - rs1571069 - rs2274389 - rs1408047 - rs2281886 - rs2281885 - rs4743 - rs2296147		TEX30	Haplotypic association:TDT: Global P-value = 0.013 in CNG family series; Global P-value = 0.6 in NIMH genetic initiative pedigrees	Significant association was found in CNG family series. Significant association was found in CNG family series.	Positive