BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Basic Info

Reference	Zandi, P. P.,2007 PMID: 17505464
Citation	Zandi, P. P., J. A. Badner, et al. (2007). "Genome-wide linkage scan of 98 bipolar pedigrees and analysis of clinical covariates." Mol Psychiatry 12(7): 630-639.
Disease Type	Bipolar Disorder
Study Design	pedigree
Study Type	Genome-wide linkage study
Sample Size	428 subjects in 98 BP families
SNP/Region/Marker Size	402 microsatellite markers for whole genome wide
Predominant Ethnicity
Population	American

Detail Info

Sample Diagnosis	RDC
Sample Status	The 98 new BP pedigrees in this study were ascertained based on a treated bipolar I (BPI) proband plus at least two first-degree relatives with a major mood disorder, defined as schizoaffective disorder, manic type (SAM), BPI, bipolar II disorder with recurrent major depression (BPII) or recurrent major depression (MDDR). Recruitment for this study, now referred to as CHIP, was conducted at University of Chicago, Johns Hopkins, and the NIMH Intramural Program. The final sample after all corrections included 428 genotyped subjects in 98 pedigrees. Of these, 282 were diagnosed with a major mood disorder, including four with SAM, 121 with BPI, 80 with BPII and 77 with MDDR. Under the narrow affection status model defined below, there were 71 independent sib pairs, 86 all possible sib pairs and 120 relative pairs. Under the broad affection status model, there were 123 independent sib pairs, 162 all possible sib pairs and 239 relative pairs .Major mood disorder is defined as having schizoaffective disorder, manic type (SAM), bipolar I disorder (BPI), bipolar II disorder with recurrent major depression (BPII), or recurrent major depression (MDDR); the narrow model includes SAM, BPI or BPII, and the broad model includes SAM, BPI, BPII or MDDR.
Technique	genotyping
Statistical Method	non-parametric linkage analysis
Result Summary	In the non-parametric linkage analysis, three loci were nominally significant under a narrow diagnostic model and seven other loci were nominally significant under a broader model. The top findings were on chromosomes 2q24 and 3q28.

Regions reported by this study for BD (count: 10)

Region	Statistical Values	Author Comments	Result Category
12p11	Linkage analyses: for broad model, NPL(P-value) = 1.87(0.03), LOD(P-value) = 0.97(0.02)	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
12q23	Linkage analyses: for broad model, NPL(P-value) = 1.77(0.04), LOD(P-value) = 0.74(0.03)	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
15q22	Linkage analyses: for narrow model, NPL(P-value) = 1.67(0.05), LOD(P-value) = 0.75(0.03)	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
19q13	Linkage analyses: for broad model, NPL(P-value) = 1.67(0.05), LOD(P-value) = 1.09(0.013)	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
10q26	Linkage analyses: for broad model, NPL(P-value) = 1.66(0.05), LOD(P-value) = 0.79(0.03)	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
9p24	Linkage analyses: for broad model, NPL(P-value) = 1.6(0.05), LOD(P-value) = 0.65(0.04)	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
7q22	Linkage analyses: for broad model, NPL(P-value) = 1.75(0.04), LOD(P-value) = 1(0.02)	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
3q28	Linkage analyses: for broad model, NPL(P-value) = 2.4(0.008), LOD(P-value) = 1.94(0.0014)	Suggestive linkage was found in this region. Suggestive linkage was found in this region.	Trend
2q24	Linkage analyses: for narrow model, NPL(P-value) = 2.54(0.005), LOD(P-value) = 1.99(0.0012); for broad model, NPL(P-value) = 2.04(0.02), LOD(P-value) = 1.32(0.007)	Suggestive linkage was found in this region. Suggestive linkage was found in this region.	Trend
1q44	Linkage analyses: for narrow model, NPL(P-value) = 1.78(0.04), LOD(P-value) = 0.62(0.05)	No significant linkage was found in this region. No significant linkage was found in this region.	Negative